Results 111 to 120 of about 3,471,294 (187)

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High‐Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Graphical presentation of rectal carriage of carbapenem‐resistant Klebsiella pneumoniae, highlighting ST307 high‐risk clone and IncX3 plasmid‐associated blaOXA‐181. This study highlights the threat linked to horizontal gene transfer of AMR genes by epidemic plasmids from Klebsiella pneumoniae high‐risk clones to other bacterial species.
Kafilat Taiwo Salvador‐Oke, Johann Pitout, Gisele Peirano, Kathy‐Anne Strydom, Chanel Kingsburgh, Marthie Ehlers, Marleen Kock   +6 more
wiley   +1 more source

Cefiderocol activity against planktonic and biofilm forms of β-lactamase-producing pseudomonas aeruginosa from people with cystic fibrosis

Journal of Global Antimicrobial Resistance
Objectives: Chronic Pseudomonas aeruginosa infections are a leading cause of acute pulmonary exacerbations in people with cystic fibrosis (pwCF). Intrinsic antibiotic resistance and biofilm formation complicate treatment.
Giorgia Fabrizio, Mauro Truglio, Ilaria Cavallo, Francesca Sivori, Massimo Francalancia, Rodolfo J. Riveros Cabral, Manola Comar, Maria Trancassini, Daniele Emanuele Compagnino, Fabiana Diaco, Guido Antonelli, Fiorentina Ascenzioni, Giuseppe Cimino, Fulvia Pimpinelli, Enea Gino Di Domenico   +14 more
doaj   +1 more source

Acinetobacter radioresistens Bacteremia in Complicated Pneumonia. A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Acinetobacter radioresistens, a ubiquitous non‐pathogen microorganism, is the source of the class D carbapenemase OXA‐23 being therefore a potential disseminator of resistance genes in Acinetobacter spp. At present few cases of human infections have been reported in the literature, all sensible to beta‐lactams.
Sara Campana, Francesco Giannone, Marco Torri, Carlo Rostagno   +3 more
wiley   +1 more source

Detection of blaNDM‐1 and blaIMP‐1 Metallo‐β‐Lactamases in Meropenem‐Resistant Clinical Escherichia coli Isolates Using Modified Carbapenem Inactivation Method (mCIM) and PCR Techniques

Journal of Clinical Laboratory Analysis, Volume 39, Issue 21, November 2025.
This study examines the prevalence of blaNDM‐1 and blaIMP‐1 metallo‐β‐lactamase genes in meropenem‐resistant Escherichia coli isolates using mCIM and PCR. The results indicate a higher prevalence of blaNDM‐1 and suggest the presence of alternative resistance mechanisms in some strains, emphasizing the need for further research on antimicrobial ...
Mehdi Roshdi Maleki
wiley   +1 more source

Activity of cefiderocol against Pseudomonas aeruginosa from the USA and Europe (2020–2023) with difficult-to-treat resistance phenotype, including those nonsusceptible to recently developed β-lactam/β-lactamase inhibitor combinations: results from the SENTRY antimicrobial surveillance program

Microbiology Spectrum
Cefiderocol and the β-lactam/β-lactamase inhibitor (BL-BLI) combinations ceftazidime-avibactam (CAZ-AVI), imipenem-relebactam (IMI-REL), and ceftolozane-tazobactam (TOL-TAZ) are recommended for the treatment of difficult-to-treat resistance (DTR ...
John H. Kimbrough, Maura H. Karr, Sean T. Nguyen, Boudewijn L. M. DeJonge, Chris Longshaw, Miki Takemura, Yoshinori Yamano, Mariana Castanheira, Rodrigo E. Mendes   +8 more
doaj   +1 more source

1455. Potential Mechanisms of Cefiderocol MIC Increase in Enterobacterales in In Vitro Resistance Acquisition Studies [PDF]

, 2020
Yoshinori Yamano, Rio Nakamura, Miki Takemura, Roger Echols   +3 more
openalex   +1 more source

Cefiderocol Susceptibility and Carbapenemase Profiles in Carbapenem-Resistant Enterobacterales

Infectious Diseases and Clinical Microbiology
Objective: Cefiderocol is a siderophore cephalosporin used as a last resort treatment for infections caused by carbapenem-resistant Enterobacterales (CRE), which pose a threat to public health. This study aimed to determine cefiderocol susceptibility among CRE isolates from the Western Marmara Region of Türkiye and to evaluate the association between ...
Ayça Bayrak, Alper Akçalı, Reyhan Mutlu, Nesrin Çakıcı   +3 more
openaire   +3 more sources

Assessment of sustained efficacy and resistance emergence under human-simulated exposure of cefiderocol against Acinetobacter baumannii using in vitro chemostat and in vivo murine infection models

, 2022
Christian M Gill, Kamilia Abdelraouf, Merime Oota, Rio Nakamura, Miho Kuroiwa, Yoshino Ishioka, Miki Takemura, Yoshinori Yamano, David P. Nicolau   +8 more
openalex   +1 more source

P-1224. Activity of Cefiderocol-Based Combinations Against Cefiderocol-Resistant Stenotrophomonas maltophilia Isolates

Open Forum Infectious Diseases
Abstract Background Stenotrophomonas maltophilia is a multidrug-resistant pathogen with limited therapeutic options. IDSA guidelines recommend cefiderocol (FDC) in combination with trimethoprim/sulfamethoxazole (TMP/SMX), levofloxacin (LEV), or minocycline (MIN) for empiric treatment of serious
Kunz Coyne, Ashlan J, Gray, Rachel, Do, Alex   +2 more
openaire   +2 more sources

Widespread cefiderocol heteroresistance in carbapenem-resistant Gram-negative pathogens [PDF]

The Lancet Infectious Diseases, 2021
Jacob E, Choby, Tugba, Ozturk, Sarah W, Satola, Jesse T, Jacob, David S, Weiss   +4 more
openaire   +2 more sources