Results 1 to 10 of about 17,696 (197)

Genetic and clinical determinants of tacrolimus accumulation in early liver transplantation: evidence for a combined genotype-antibiotic effect [PDF]

Annals of Medicine
Background Tacrolimus is a first-line immunosuppressant essential for preventing graft rejection after liver transplantation, but its narrow therapeutic index and extensive interindividual pharmacokinetic variability complicate optimal dosing during the ...
Jinlin Guo, Shiying Feng, Zifan Feng, Jinyan Yang, Xinfeng Cai, Xingang Li, Rui Zhang   +6 more
doaj   +2 more sources

Severe delayed coagulopathy caused by cefoperazone/sulbactam: A case report [PDF]

Journal of International Medical Research
This case report described a suspected severe coagulopathy attributed to cefoperazone/sulbactam, and this adverse reaction might be associated with the inhibition of the vitamin K cycle by cefoperazone/sulbactam, leading to vitamin K deficiency within ...
Siqin Sun, Yixuan Wang, Jie Min, Zhidan Wang, Lei Yu   +4 more
doaj   +2 more sources

Case Report: Anaphylactic shock induced by cefoperazone sodium and sulbactam sodium for injection [PDF]

Frontiers in Medicine
RationaleCefoperazone-sulbactam is a widely used antibiotic in clinical practice, and anaphylactic shock is a severe adverse drug reaction. Previous literature has rarely reported cases of anaphylactic shock induced by cefoperazone-sulbactam.Patient ...
Weiqian Liu, Weiqian Liu, Bo Gao, Shaowei Xie, Shaowei Xie, Dongrui Yan, Dongrui Yan, Yu Yin, Yu Yin   +8 more
doaj   +2 more sources

Perioperative antibiotic prophylaxis in surgery

Perioperative Medicine, 2021
Infectious complications in surgery occupy a significant place among the causes of death and increase in the cost of medical care for various pathologies.
Dmytro Dmytriiev, Oleksandr Nazarchuk, Yuliana Babina   +2 more
doaj   +1 more source

Cefoperazone Induced Gastrointestinal Bleeding [PDF]

Journal of Clinical and Diagnostic Research, 2016
Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K ...
Goutham Reddy Katukuri, Raja Naga Mahesh Maddala, Kusugodlu Ramamoorthi, Manjunatha Hande   +3 more
doaj   +1 more source

Case Report: Drug-Induced Immune Haemolytic Anaemia Caused by Cefoperazone-Tazobactam/ Sulbactam Combination Therapy

Frontiers in Medicine, 2021
There has previously been a report of a patient developing haemolytic anaemia following exposure to cefoperazone. Another case has been reported involving the detection of cefoperazone-dependent antibodies in the absence of immune haemolytic anaemia.
Yuanjun Wu, Yong Wu, Yanli Ji, Jiajie Liang, Ziyi He, Yanhui Liu, Li Tang, Ganping Guo   +7 more
doaj   +1 more source

Model-Informed Drug Development of New Cefoperazone Sodium and Sulbactam Sodium Combination (3:1): Pharmacokinetic/Pharmacodynamic Analysis and Antibacterial Efficacy Against Enterobacteriaceae

Frontiers in Pharmacology, 2022
Objective: Cefoperazone/sulbactam is a commonly used antibiotic combination against the extended-spectrum beta-lactamases (ESBLs)-producing bacteria. The objective of this study was to evaluate the efficacy of a new cefoperazone/sulbactam combination (3 ...
Xi-Wei Ji, Xiao Zhu, Yun Li, Feng Xue, Isabelle Hui San Kuan, Isabelle Hui San Kuan, Qing-Feng He, Xiang-Rui Meng, Xiao-Qiang Xiang, Yi-Min Cui, Bo Zheng   +10 more
doaj   +1 more source

RATIONAL USE OF 3rd GENERATION CEPHALOSPORINS IN TERTIARY CARE HOSPITALS: A CONCURRENT DUR

International Journal of Pharmacy & Integrated Health Sciences, 2022
Background: Assessment of use of antimicrobials can be performed by evaluating their use. Drug use evaluation is a performance improvement method that concentrates on improvement and evaluation of drug use processes to achieve optimal patient outcomes.
doaj   +1 more source

Combined PK/PD Index May Be a More Appropriate PK/PD Index for Cefoperazone/Sulbactam against Acinetobacter baumannii in Patients with Hospital-Acquired Pneumonia

Antibiotics, 2022
Cefoperazone/sulbactam (CPZ/SUL) is a β-lactam and β-lactamase inhibitor combination therapy for the treatment of respiratory tract infections. Using data from a prospective, multiple-center, open-label clinical trial in 54 patients with hospital ...
Yingjie Zhou, Jing Zhang, Yuancheng Chen, Jufang Wu, Beining Guo, Xiaojie Wu, Yingyuan Zhang, Minggui Wang, Ru Ya, Hao Huang   +9 more
doaj   +1 more source

Quorum Sensing Inhibiting Activity of Cefoperazone and Its Metallic Derivatives on Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2021
The last decade has witnessed a massive increase in the rate of mortalities caused by multidrug-resistant Pseudomonas aeruginosa. Therefore, developing new strategies to control virulence factors and pathogenicity has received much attention.
Nourhan G. Naga, Dalia E. El-Badan, Heba S. Rateb, Khaled M. Ghanem, Mona I. Shaaban   +4 more
doaj   +1 more source