Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections
ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are among the most common opportunistic pathogens in nosocomial infections. Herein, contemporary therapeutic strategies against drug‐resistance ESKAPE and antimicrobial agents with prospective ...
Yu‐Xuan Ma +7 more
wiley +1 more source
This study was conducted to develop a rapid, simple and reproducible method for the quantification of ceftaroline in plasma samples by high-performance liquid chromatography with ultraviolet detection (HPLC-UV).
Ana Alarcia-Lacalle +7 more
doaj +1 more source
Ceftaroline Fosamil for the Treatment of Community-Acquired Pneumonia: from FOCUS to CAPTURE. [PDF]
Ceftaroline fosamil (ceftaroline hereafter) is the latest addition to the armamentarium for the treatment of patients with community-acquired pneumonia (CAP).
Carreno JJ, Lodise TP.
europepmc +2 more sources
Background: To compare the real-life effectiveness and safety of ceftaroline fosamil (ceftaroline-F) and ceftobiprole medocaril (ceftobiprole-M) for infections in hospitalized patients.
Daniel Arnés García +6 more
doaj +1 more source
Quantification of drugs is an essential part for ensuring quality, safety and efficacy of pharmaceutical formulations. For this, validated methods must be used in order to guarantee analytical reliability during monitoring in clinical studies and ...
Lilian F. Machioli +3 more
doaj +1 more source
Multicenter Observational Study of Ceftaroline Fosamil for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections. [PDF]
Novel therapies for methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) are needed in the setting of reduced antibiotic susceptibilities and therapeutic failure.
Zasowski EJ +8 more
europepmc +3 more sources
Safety and Efficacy of Ceftaroline Fosamil in the Management of Community-Acquired Bacterial Pneumonia [PDF]
Ceftaroline fosamil is a new fifth-generation cephalosporin indicated for the treatment of community-acquired bacterial pneumonia (CABP). It possesses antimicrobial effects against both Gram-positive and Gram-negative bacteria, including methicillin ...
DeBellis, Heather F +1 more
core +1 more source
FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia [PDF]
Objectives: Ceftaroline, the active form of the prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated with community-acquired pneumonia (CAP), including Streptococcus pneumoniae and ...
Eckburg, Paul B. +12 more
core +1 more source
Bacterial Spinal Epidural and Psoas Abscess in Pregnancy Associated with Intravenous Drug Use
Spontaneous spinal epidural abscess (SEA) is a rare infection of the central nervous system. We report a case of a 25‐year‐old G3 P0020 at 36 weeks of gestational age with history of intravenous drug abuse presenting with acute‐onset and severe back pain. Despite antibiotic therapy, pain worsened and she developed lower extremity weakness.
Tirtza N. Spiegel Strauss +3 more
wiley +1 more source
Ceftaroline fosamil: drug profile and clinical data
Several studies have shown that the rates of resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus, vancomycin-intermediate S.
Zeina A Kanafani, Kanafani Z.A.
core +1 more source

