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Ceftazidime is a 3rd generation cephalosporin active against Pseudomonas aeruginosa. Avibactam is an inhibitor of class A, C and some class D β-lactamases. The antibacterial spectrum of ceftazidime-avibactam covers 95% of P. aeruginosa isolates and >99% of enterobacteria, including strains carrying extended-spectrum β-lactamases (ESBLs).
Matesanz, Mayra, Mensa, José
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Ceftazidime-avibactam in ceftazidime-resistant infections [PDF]
One of the important causes of the development of resistance to β-lactam drugs is their overuse. β-lactamase inhibitors have been combined with many β-lactam drugs to resume their efficacy since the emergence of multidrugresistant organisms. Yahuda Carmeli and colleagues recommended the combination of ceftazidimeavibactam as a potential alternative to ...
Yehuda, Carmeli +4 more
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The increase in nosocomial infections by beta-lactamase producing Gram-negative bacilli constitutes a therapeutic challenge. The combination of ceftazidime-avibactam offers a very interesting therapeutic option for nosocomial pneumonia caused by extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, multidrug-resistant Pseudomonas aeruginosa,
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Latar belakang. Terapi antibiotik empiris spektrum luas merupakan standar pengobatan demam neutropenia pada keganasan karena morbiditas dan mortalitas yang berhubungan dengan sepsis bakterial.
Agustinus William +3 more
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Poly(styrene-alt-maleic anhydride) Conjugated with Spermine: Synthesis, Antibacterial Activity and Antibiotic Susceptibility [PDF]
Hypothesis: In the past decades, the increasing resistance to antibiotics among some nosocomial infection pathogens has been one of the largest challenges of human health. One of the ways to reduce antibiotic resistance in bacteria is the combination use
Jalil Javedani Bafekr +3 more
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In silico ADME and Toxicity Prediction of Ceftazidime and Its Impurities
To improve the quality control of drugs, we predicted the absorption, distribution, metabolism, excretion, and toxicity (ADMET) of ceftazidime (CAZ) and its impurities via in silico methods.
Ying Han +5 more
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Introduction: Klebsiella pneumoniae are Gram-negative which cause many diseases such as urinary tract infections, respiratory tract infections and septicemia. Inulinase is an enzyme used in food manufacture and pharmaceuticals.
Sarah Naji Aziz +11 more
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BACKGROUND: Urine samples constitute a major proportion of the samples tested in routine diagnostic laboratories. Nitrofurination used to treat urinary tract infection (UTI) for both Gram-positive and negative bacteria.
Falah Hasan Obayes Al-Khikani +2 more
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Corrosion Behaviour of Mild Steel in Sulphuric Acid Solution in Presence of Ceftazidime
The corrosion inhibition properties of ceftadizime (CZD) for mild steel corrosion .in H2SO4 solution were analysed by electrochemical impedance spectroscopy (EIS), potentiodynamic polarization and gravimetric methods.
Ashish Kumar Singh +2 more
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IntroductionThis study aimed to investigate the mechanism underlying a peculiar resistance phenotype in Klebsiella pneumoniae, characterized by reduced susceptibility to cefepime compared to ceftazidime.MethodsAntimicrobial susceptibility testing ...
Peishan Li +5 more
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