Results 91 to 100 of about 8,708 (251)

Safety and Efficacy of Ceftolozane/Tazobactam Versus Meropenem in Neonates and Children With Complicated Urinary Tract Infection, Including Pyelonephritis: A Phase 2, Randomized Clinical Trial

open access: yesThe Pediatric Infectious Disease Journal, 2023
Background: Ceftolozane/tazobactam, a cephalosporin-β-lactamase inhibitor combination, active against multidrug-resistant Gram-negative pathogens, is approved for treatment of adults with complicated urinary tract infections (cUTI).
E. Roilides   +11 more
semanticscholar   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

open access: yesMedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy   +9 more
wiley   +1 more source

Discrepancies in Beta‐Lactam Antibiotics Cross‐Reactivity: Implications for Clinical Practice

open access: yesAllergy, Volume 80, Issue 11, Page 3108-3114, November 2025.
Four studies previously published on beta‐lactam antibiotics cross‐reactivity were compared head‐to‐head. These studies covered 51 antibiotics, theoretically leading to 2550 potential recommendations regarding alternatives in case of specific allergies. The studies analysed different sets of beta‐lactam antibiotics.
Evelien Maria Hutten   +4 more
wiley   +1 more source

The epidemiological landscape of bloodstream infections in children undergoing chemotherapy or haematopoietic cell transplantation: A retrospective study by Infectious Diseases Working Group of Italian Association of Pediatric Hematology and Oncology (AIEOP)

open access: yesBritish Journal of Haematology, Volume 207, Issue 5, Page 1982-1993, November 2025.
Summary Understanding bloodstream infection (BSI) epidemiology is crucial for optimizing antibiotic therapy in paediatric haematology–oncology patients undergoing chemotherapy or haematopoietic cell transplantation (HCT). However, updated paediatric data remain scarce.
Francesco Baccelli   +35 more
wiley   +1 more source

Ceftolozane/tazobactam: Novelantipseudomonal cephalosporin [PDF]

open access: yesPharmacy Today, 2015
Abstract Another much-needed antibiotic enters the marketplace with FDA'sapproval of ceftolozane/tazobactam (Zerbaxa—Cubist) for the treatmentof adult patients with complicated intra-abdominal infections(cIAI) in combination with metronidazole and for complicated urinarytract infections (cUTI), including pyelonephritis.
openaire   +1 more source

Management of intra-abdominal infections : recommendations by the WSES 2016 consensus conference [PDF]

open access: yes, 2017
This paper reports on the consensus conference on the management of intra-abdominal infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual World Society of Emergency Surgery (WSES) meeting. This document covers all
A Betsch   +319 more
core   +4 more sources

Healthcare Resource Utilization of Ceftolozane/Tazobactam Versus Meropenem for Ventilated Nosocomial Pneumonia from the Randomized, Controlled, Double-Blind ASPECT-NP Trial

open access: yesInfectious Diseases and Therapy, 2020
Introduction Hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP) are associated with significant healthcare resource utilization (HCRU).
Thomas Lodise   +4 more
doaj   +1 more source

A review of antibiotic safety in pregnancy—2025 update

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen   +8 more
wiley   +1 more source

Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates

open access: yesCase Reports in Infectious Diseases, 2016
Stenotrophomonas maltophilia is an inherently multidrug resistant (MDR) opportunistic pathogen with many mechanisms of resistance. SENTRY studies reveal decreasing sensitivities of S.
Jeffrey C. Jolliff   +4 more
doaj   +1 more source

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