Results 81 to 90 of about 8,708 (251)

Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors?

Antimicrobial Agents and Chemotherapy
Paired baseline and post-exposure isolates from 34 patients who developed ceftolozane–tazobactam (TOL-TAZ) resistance following treatment of multidrug-resistant (MDR) Pseudomonas aeruginosa infections were analyzed to determine if ceftolozane with an ...
Ava J. Dorazio, Ellen G. Kline, Kevin M. Squires, J. Pogue, D. Van Tyne, R. K. Shields   +5 more
semanticscholar   +1 more source

Comparing ceftolozane/tazobactam versus piperacillin/tazobactam as empiric therapy for complicated urinary tract infection in Taiwan: A cost-utility model focusing on gram-negative bacteria

Journal of Microbiology, Immunology and Infection, 2019
Background: Complicated urinary tract infection (cUTI) is often associated with drug-resistant pathogens and requires therapy with broad-spectrum antibiotics.
Guan-Jhou Chen, Sung-Ching Pan, Jason Foo, Chaienna Morel, Wei-Ting Chen, Jann-Tay Wang   +5 more
doaj   +1 more source

Ceftolozane/tazobactam – the "new player" in a battle against multiresistant pathogens [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Ceftolozane/tazobactam is a new combined antibacterial agent for the treatment of infections caused by gram-negative microorganisms, P. aeruginosa in particular, including strains resistant to other clinically available antimicrobials.
Golub A.V., Kozlov R.S.
doaj   +1 more source

In vitro activity of ceftolozane/tazobactam against Gram‐negative isolates collected from ICU patients with lower respiratory tract infections in seven Asian countries—SMART 2017–2019

Journal of Global Antimicrobial Resistance, 2022
Objectives: Antimicrobial resistance is one of the top 10 global public-health threats. Especially high rates of resistance have been reported for isolates from ICU patients, requiring expanded treatment options in this setting. We evaluated the activity
Sibylle H. Lob, Krystyna M. Kazmierczak, Wei-Ting Chen, Fakhar Siddiqui, C. Andrew DeRyke, Katherine Young, Mary R. Motyl, Daniel F. Sahm   +7 more
doaj   +1 more source

Rapid valve sterilization with meropenem plus ceftolozane/tazobactam combination therapy for <i>Pseudomonas aeruginosa</i> prosthetic valve endocarditis. [PDF]

JAC Antimicrob Resist
Background Pseudomonas aeruginosa infective endocarditis (IE) presents a significant clinical challenge, leading to high rates of treatment failure and mortality.
Alaguvel V, Khetarpal AK, Jankeel A, Tapia-Cano WA, Martinez G, Lorenzana A, Hsiao Z, Rose W, Sakoulas G, Ulloa ER.   +9 more
europepmc   +2 more sources

Cyclic Boronates Inhibit All Classes of β-Lactamase [PDF]

, 2017
β-Lactamase-mediated resistance is a growing threat to the continued use of β-lactam antibiotics. The use of the β-lactam-based serine-β-lactamase (SBL) inhibitors clavulanic acid, sulbactam, tazobactam, and, more recently, the non-β-lactam inhibitor ...
Brem, J, Cahill, ST, Cain, R, Fishwick, CWG, Lohans, CT, McDonough, MA, Mohammed, J, Oswin, HP, Schofield, CJ, Spencer, J, Wang, DY, Wareham, DW   +11 more
core   +5 more sources

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

In vitro synergistic antimicrobial activity of a combination of meropenem, colistin, tigecycline, rifampin, and ceftolozane/tazobactam against carbapenem-resistant Acinetobacter baumannii

Scientific Reports, 2022
We investigated the in vitro activity of various antimicrobial combinations against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. The in vitro activity of six two-drug combinations against CRAB isolates collected from the blood samples of
Yong Guk Ju, Hak Joon Lee, Hong Soon Yim, Min-Goo Lee, Jang Wook Sohn, Young Kyung Yoon   +5 more
doaj   +1 more source

Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland [PDF]

, 2017
The increasing incidence of carbapenem-resistant Klebsiella pneumoniae is a major challenge to public health. Despite the fact that the prevalence of carbapenemases among carbapenem-resistant K.
Bassi, Cécile, Lienhard, Reto, Mancini, Stefano, Nordmann, Patrice, Poirel, Laurent, Tritten, Marie-Lise   +5 more
core   +1 more source

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High‐Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Graphical presentation of rectal carriage of carbapenem‐resistant Klebsiella pneumoniae, highlighting ST307 high‐risk clone and IncX3 plasmid‐associated blaOXA‐181. This study highlights the threat linked to horizontal gene transfer of AMR genes by epidemic plasmids from Klebsiella pneumoniae high‐risk clones to other bacterial species.
Kafilat Taiwo Salvador‐Oke, Johann Pitout, Gisele Peirano, Kathy‐Anne Strydom, Chanel Kingsburgh, Marthie Ehlers, Marleen Kock   +6 more
wiley   +1 more source