Results 101 to 110 of about 58,334 (260)

Children's International Polyposis (CHIP) study : a randomized, double-blind, placebo-controlled study of celecoxib in children with familial adenomatous polyposis [PDF]

, 2017
Objective: To evaluate the efficacy and safety of celecoxib versus placebo in the prevention and treatment of colorectal polyposis in children with familial adenomatous polyposis (FAP).
Berger, Manuela F, Burke, Carol A, Dhooge, Catharina, Essex, Margaret Noyes, Iorga, Dinu, Li, Chunming, Lynch, Patrick M, Peeters, Marc, Phillips, Robin, study site investigators, the   +9 more
core   +2 more sources

Molecular docking evaluation of celecoxib on the boron nitride nanostructures for alleviation of cardiovascular risk and inflammatory

, 2021
Yan Cao, Maryam Noori, Marziyeh Nazari, Andrew Ng Kay Lup, Alireza Soltani, Vahid Erfani‐Moghadam, Aref Salehi, Mehrdad Aghaei, Md Lutfor Rahman, Mohd Sani Sarjadi, Shaheen M. Sarkar, Chia‐Hung Su   +11 more
openalex   +1 more source

Combined Therapy with Rosiglitazone, Rofecoxib and Celecoxib Enhances Cardiovascular Side Effects through Cytochrome P450 Pathway of Arachidonic Acid Metabolism in Diabetic Arthritis Model Rats [PDF]

, 2020
Xuya Zhou, Ying Liu, Deqin Xu, Jie Bao, Yaru Cao, Yong Jin   +5 more
openalex   +1 more source

Polygonum cognatum Extract: Multitarget Anti‐inflammatory, Antidiabetic, and Epigenetic Modulation Properties

ChemistryOpen, Volume 15, Issue 2, February 2026.
Polygonum cognatum extracts exhibit strong antioxidant, anti‐inflammatory, antidiabetic, and antimicrobial activities. This study demonstrates, for the first time, histone deacetylase inhibitory activity, revealing epigenetic modulation potential.
Serhat Karaman, Yakup Budak, Elif Aktürk Bozdemir   +2 more
wiley   +1 more source

Computer-Aided Drug Repurposing: A Cyclooxygenase-2 Inhibitor Celecoxib as a Ligand for Estrogen Receptor Alpha

Indonesian Journal of Chemistry, 2015
A cyclooxygenase-2 (COX-2) inhibitor celecoxib has been previously reported to have cytotoxic activities towards gastric, prostate, ovarian, colon and breast cancer cell lines.
Enade Perdana Istyastono, Florentinus Dika Octa Riswanto, Sri Hartati Yuliani   +2 more
doaj   +1 more source

Future directions for the management of pain in osteoarthritis. [PDF]

, 2014
Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA
Aigner T, Anasuya Kuttapitiya, Balanescu AR, Bannuru RR, Chou R, da Costa BR, Danielsson L, Fanelli A, Fransen M, Haviv B, Huskisson EC, Lim YZ, Mankin HJ, McAlindon TE, Merlotti D, Nguyen US, Nidhi Sofat, Pelletier JP, Sagar DR, Sellers RS, Sofat N, Tannenbaum H, Wajed J, Wakitani S   +23 more
core   +1 more source

Predicting Pharmacological Treatment Response in Migraine Using AI/ML: A Scoping Review of the Evidence and Future Directions

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT The treatment of migraine is hampered by inter‐individual variability, leading to an inefficient “trial and error” approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therapeutic outcomes.
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Electrooxidative Divergent Halocyclizations of Ambident Amides

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Electrooxidation enables tunable halocyclization of ambident amides, yielding either C–O or C–N products through ionic or radical pathways, respectively. While detailed experimental and analytical mechanistic studies highlight mode‐dependent selectivity, in silico experimentation provided insight into the energetic origin of this divergence.
Minki Jeon, Debajit Maiti, Geon Kang, Jinwoo Kim, Isaac Choi   +4 more
wiley   +2 more sources

Cancer recording and mortality in the General Practice Research Database and linked cancer registries.

, 2013
PURPOSE: Large electronic datasets are increasingly being used to evaluate healthcare delivery. The aim of this study was to compare information held by cancer registries with that of the General Practice Research Database (GPRD).
Beral, Berkel, Bullard, Coleman, Gulliford, Møller, Phekoo, Schouten, Staa, Williams, Woods   +10 more
core   +1 more source

Bayesian Network Meta‐Analysis With One or Two Continuous Outcomes Measured at Multiple Time Points Using Gaussian Random Walks With Drift

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT Network meta‐analysis of randomized controlled trials is traditionally conducted on a single outcome measured at one time point. However, many trials also feature a secondary outcome and both outcomes may have been reported at multiple time points. Existing network meta‐analysis methods for synthesizing continuous outcome data from such trials
Pai‐Shan Cheng, Bruno R. da Costa, George Tomlinson   +2 more
wiley   +1 more source