Results 41 to 50 of about 66,137 (309)

Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats

World Journal of Gastroenterology, 2020
BACKGROUND Endoplasmic reticulum (ER) stress is an important mechanism in the progression of chronic and acute liver diseases, especially in the progression and recovery of liver fibrosis. Excessive and long-term ER stress induces apoptosis.
W. Su, Y. Tai, Shi Tang, Yanting Ye, Chong Zhao, Jinhang Gao, B. Tuo, Cheng-Wei Tang   +7 more
semanticscholar   +1 more source

Metronomic Celecoxib Therapy in Clinically Available Dosage Ablates Hepatocellular Carcinoma via Suppressing Cell Invasion, Growth, and Stemness in Pre-Clinical Models

Frontiers in Oncology, 2020
ObjectiveTo investigate the anti-carcinogenic effect of metronomic Celecoxib (i.e., frequent administration in clinically available doses) against hepatocellular carcinoma (HCC) in the perspective of metastasis, spontaneous hepatocarcinogenesis, cancer ...
Chun-Chieh Yeh, Chun-Chieh Yeh, Pei-Ying Liao, Pei-Ying Liao, Sudhir Pandey, Su-Yung Yung, Hsueh-Chou Lai, Hsueh-Chou Lai, Long-Bin Jeng, Long-Bin Jeng, Wei-Chun Chang, Wei-Chun Chang, Wen-Lung Ma, Wen-Lung Ma, Wen-Lung Ma, Wen-Lung Ma   +15 more
doaj   +1 more source

Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation

npj Biofilms and Microbiomes, 2020
Celecoxib has been effective in the prevention and treatment of chronic inflammatory disorders through inhibition of altered cyclooxygenase-2 (COX-2) pathways.
E. Hernandez-Sanabria, Evelien Heiremans, M. Calatayud Arroyo, R. Props, L. Leclercq, J. Snoeys, T. van de Wiele   +6 more
semanticscholar   +1 more source

The Effect of Lower-Limb Exercise on Pain Management of the Patients Undergoing Posterior Lumbar Fusion Surgery: A Retrospective Case-Control Study

Pain Research and Management, 2021
Purpose. The purpose of this study is to investigate the clinical effect of lower-limb exercise, when combined with celecoxib, on pain management of patients undergoing posterior lumbar fusion surgeries. Methods.
Tong Wu, Yong Ye
doaj   +1 more source

Understanding the NSAID related risk of vascular events [PDF]

, 2006
Concern is growing about an increased risk of thrombotic events (including myocardial infarction and stroke) during the use of non-steroidal anti-inflammatory drugs (NSAIDs), in particular the so called selective cyclo-oxygenase-2 (COX 2) inhibitors ...
Brouwers, Jacobus R.B.J., Laar, Mart A.F.J. van de, Vonkeman, Harald E.   +2 more
core   +4 more sources

Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.

PLoS ONE, 2021
Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolaemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study.
Martins Ekor, Phyllis Elsie Owusu Agyei, Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Meshack Antwi-Adjei, Ewura Seidu Yahaya, Gordon Amoakohene, Patrick Kafui Akakpo   +8 more
doaj   +1 more source

Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. [PDF]

, 2014
Complex interactions between the immune system and the brain might have important aetiological and therapeutic implications for neuropsychiatric brain disorders.
Cousins, Lesley, Deakin, Julia, Jones, Peter B., Khandaker, Golam M., Lennox, Belinda R., Yolken, Robert   +5 more
core   +2 more sources

Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.

New England Journal of Medicine, 2016
BACKGROUND The cardiovascular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs), remains uncertain. METHODS Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased ...
S. Nissen, N. Yeomans, D. Solomon, T. Lüscher, P. Libby, M. Husni, D. Y. Graham, J. Borer, Lisa M Wisniewski, K. Wolski, Qiuqing Wang, V. Menon, F. Ruschitzka, M. Gaffney, B. Beckerman, M. Berger, W. Bao, A. Lincoff   +17 more
semanticscholar   +1 more source

Formulation, Characterization, and in Vivo Evaluation of Celecoxib-PVP Solid Dispersion Nanoparticles Using Supercritical Antisolvent Process

Molecules, 2014
The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process.
Eun-Sol Ha, Gwang-Ho Choo, In-Hwan Baek, Min-Soo Kim   +3 more
doaj   +1 more source

The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. [PDF]

, 2014
The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide.
Berman, Helen M, Bi, Chunxiao, Bluhm, Wolfgang F, Bourne, Philip E, Burley, Stephen K, Christie, Cole H, Dutta, Shuchismita, Goodsell, David S, Green, Rachel Kramer, Prlić, Andreas, Rose, Peter W, Westbrook, John D, Woo, Jesse, Young, Jasmine, Zardecki, Christine   +14 more
core   +4 more sources