Results 1 to 10 of about 1,646,961 (327)

Intraoperative Strategies for Minimal Manipulation of Autologous Adipose Tissue for Cell‐ and Tissue‐Based Therapies: Concise Review [PDF]

Stem Cells Translational Medicine, 2019
The stromal vascular fraction (SVF) is a heterogeneous population of stem/stromal cells isolated from perivascular and extracellular matrix (ECM) of adipose tissue complex (ATC). Administration of SVF holds a strong therapeutic potential for regenerative
Angelo Trivisonno, Robert W. Alexander, Silvia Baldari, Steven R. Cohen, Giuliana Di Rocco, Pietro Gentile, Guy Magalon, Jérémy Magalon, Randy B. Miller, Hayley Womack, Gabriele Toietta   +10 more
doaj   +4 more sources

Concise Review: Mind the Gap: Challenges in Characterizing and Quantifying Cell- and Tissue-Based Therapies for Clinical Translation [PDF]

Stem Cells, 2010
Abstract There are many challenges associated with characterizing and quantifying cells for use in cell- and tissue-based therapies. From a regulatory perspective, these advanced treatments must not only be safe and effective but also be made by high-quality manufacturing processes that allow for on-time delivery of viable products ...
Rayment, Erin A., Williams, David J.
openaire   +5 more sources

Report of a clinical and laboratory management of cell therapy for knee cartilage in the face of mycoplasma contamination [PDF]

Einstein (São Paulo), 2022
To describe a case of autologous chondrocyte implantation after cell culture contamination by Mycoplasma pneumoniae and the measures taken to successfully complete cell therapy in a patient with focal chondral lesion.
Alessandro Rozim Zorzi, Eliane Antonioli, Juliana Aparecida Preto de Godoy, Oswaldo Keith Okamoto, Andrea Tiemi Kondo, José Mauro Kutner, Camila Cohen Kaleka, Moisés Cohen, Mario Ferretti   +8 more
doaj   +1 more source

The potential key genes and pathways associated with Wilms tumor in quest of proper candidates for diagnostic and therapeutic purposes

Scientific Reports, 2022
To designate the probable most important differentially expressed genes and genetic pathways in Wilms tumor and assess their expression and diagnostic potential by RT-PCR and statistical analysis.
Masoud Bitaraf, Mohammadamin Mahmanzar, Narges Zafari, Hadiseh Mohammadpour, Mohammad Vasei, Leyla Moradi Matin, Abdol-Mohammad Kajbafzadeh, Masoumeh Majidi Zolbin   +7 more
doaj   +1 more source

Pediatric Drug Development: Reviewing Challenges and Opportunities by Tracking Innovative Therapies

Pharmaceutics, 2023
The paradigm of pediatric drug development has been evolving in a “carrot-and-stick”-based tactic to address population-specific issues. However, the off-label prescription of adult medicines to pediatric patients remains a feature of clinical practice ...
Cátia Domingues, Ivana Jarak, Francisco Veiga, Marília Dourado, Ana Figueiras   +4 more
doaj   +1 more source

Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines: Good Practice for Better Therapies

Stem Cells Translational Medicine, 2022
Abstract The development of cell-, gene- and tissue engineering (CGT)-based therapies must adhere to strict pharmaceutical quality management standards, as for any other biological or small-molecule drug. However, early developments often failed to fully comply with good laboratory practices (GLP) in non-clinical safety studies.
Luis Lopez-Navas, Sílvia Torrents, Rosario Sánchez-Pernaute, Joaquim Vives   +3 more
openaire   +5 more sources

Therapeutic role of mesenchymal stem cell-derived exosomes in respiratory disease

Stem Cell Research & Therapy, 2022
Exosomes are extracellular vesicles found in various tissues, blood circulation, and tissue fluids, secreted into the extracellular environment by fusing a multivesicular body with a plasma membrane.
Mehdi Jahedi Zargar, Saeid Kaviani, Mohammad Vasei, Mina Soufi Zomorrod, Saeed Heidari Keshel, Masoud Soleimani   +5 more
doaj   +1 more source

Autologous Natural Killer Cell-enrichment for Immune Cell Therapy: Preclinical Setting Phase, Shiraz Experience

Iranian Journal of Allergy, Asthma and Immunology, 2021
Natural killer (NK) cell therapy has proven to be a promising approach for the treatment of malignancies. Osaki method for ex-vivo autologous NK cell expansion has been recently introduced in Japan. To start clinical trial phase I at Shiraz University of
Somayeh Rezaeifard, Yuji Heike, Jun-Ichi Masuyama, Alireaz Rezvani, Reza Vojdani, Nasrollah Erfani   +5 more
doaj   +1 more source

Perspectives of chitosan nanofiber/film scaffolds with bone marrow stromal cells in tissue engineering and wound dressing [PDF]

Nanomedicine Journal, 2019
Objective (s): Several methods have been proposed for repairing defects and damages, one of which is cell therapy. Bone marrow stromal cells seem to be suitable for this purpose. On the other hand, many biometric materials are used to improve and correct
Mohsen Rahimi, Asgar Emamgholi, Seyyed Javad Seyyed Tabaei, Mahdi Khodadoust, Hojat Taghipour, Ameneh Jafari   +5 more
doaj   +1 more source

Computer simulation of glioma growth and morphology [PDF]

, 2007
Despite major advances in the study of glioma, the quantitative links between intra-tumor molecular/cellular properties, clinically observable properties such as morphology, and critical tumor behaviors such as growth and invasiveness remain unclear ...
Adam, Ambrosi, Ambrosi, Anderson, Anderson, Anderson, Anderson, Araujo, Augustin, Bartels, Bello, Bellomo, Berger, Bernsen, Bernsen, Boegler, Brandt, Bullitt, Byrne, Byrne, Byrne, Byrne, Cai, Carmeliet, Chaplain, Chaplain, Chaplain, Chaplain, Condeelis, Cristini, Cristini, Cursiefen, DeJaeger, Derycke, Eble, Elaine L. Bearer, Ellis, Elvin, Fallenstein, Frieboes, Friedl, Friedl, Friedl, Friedman, Garcke, Gatenby, Giese, Greenspan, Hayot, Helmlinger, Hermann B. Frieboes, Holash, Holash, Huang, Jacqmin, Jain, Jain, John S. Lowengrub, Keller, Khoshyomn, Kim, Kim, Kim, Kopfstein, Kuiper, Kumar, Kunkel, Lah, Lamszus, Lee, Leo, Less, Li, Li, Lockett, Lowengrub, Macklin, Macklin, McDougall, McLean, Naganuma, O'Connor, Ommaya, Padera, Page, Patan, Patan, Paul Macklin, Pennacchietti, Plank, Plank, Preusser, Ridley, Rofstad, Rubenstein, S. Wise, Sahai, Sanga, Seftor, Shweiki, Sierra, Sinek, Skinner, Steeg, Sun, Takano, Toker, Tysnes, Vajkoczy, van Kempen, Vittorio Cristini, Wise, Wolf, Wurzel, X. Zheng, Yamaguchi, Yin, Zheng   +117 more
core   +1 more source