Results 41 to 50 of about 1,085,002 (240)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Strategies for Achieving Measurement Assurance for Cell Therapy Products

Stem Cells Translational Medicine, 2016
The cell therapy industry has identified the inability to reliably characterize cells as possibly its greatest challenge and has called for standards and reference materials to provide assurance for measurements of cell properties.
Carl G. Simon Jr., Sheng Lin-Gibson, John T. Elliott, Sumona Sarkar, Anne L. Plant   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Review on Regenerative Endodontics

Journal of Islamic Dental Association of Iran, 2014
Background and Aim : Regenerative endodontics with the goal of replacing the lost dental tissues is developing fast. The aim of this study was to review the recent progressions, known limitations and advantages of regenerative treatments compared to ...
Elham Shadmehr, Nastaran Jenabi Dehkordi
doaj  

Construction and in vitro cytotoxicity assessment of T cell receptor-engineered T cells targeting human cytomegalovirus pp65495-503 [PDF]

精准医学杂志
Objective To construct T cell receptor-engineered T (TCR-T) cells targeting human cytomegalovirus (HCMV) pp65495-503, and to evaluate their in vitro cytotoxicity against HCMV-infected glioblastoma (GBM) cells.
WANG Chen, WANG Bin, SHEN Wen, JIANG Shasha, QIAN Dongmeng
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Cell Sheet Engineering in Periodontology: A Review [PDF]

Journal of Clinical and Diagnostic Research
Cell sheet engineering has developed its own place for the regeneration of tissues. It focuses on phenomena occurring at the cellular level, whereas regenerative medicine and tissue engineering aim to create or stimulate new tissue for the treatment of ...
Ruchita Tejrao Patil, Prasad V Dhadse, Shrishti Salian   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Revolution in Cellular Aging: A Narrative Review of the Promising Role of Nanorobots in Diagnosis, Treatment, and Regenerative Medicine [PDF]

Taṣvīr-i salāmat
Nanorobots, also known as nanobots, are promising medical structures with significant potential for revolutionizing medical treatments and preventing their onset. Nanorobotics shows promise for diagnosing, treating, and regenerating age-related diseases.
Peyman Keyhanvar, Mohammad Hossein Rezaei, Hakimeh Hazrati, Solmaz Hazratgholizad, Ahmadreza Safar Bakhshayesh   +4 more
doaj   +1 more source