Results 211 to 220 of about 1,646,961 (327)

Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates. [PDF]

Nutr Metab Insights
Uti DE, Omang WA, Alum EU, Ugwu OP, Wokoma MA, Oplekwu RI, Atangwho IJ, Egbung GE.   +7 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Regeneration of the pulp-dentin complex in mature teeth using autologous demineralized dentin matrix and dental pulp stem cells: two case reports. [PDF]

BMC Oral Health
Nakashima M, Yoshihashi N, Tanaka H, Iohara K.   +3 more
europepmc   +1 more source

Tissue regeneration therapy by Nano composite scaffolds based on PLGA hydrogel embedded with human dental pulp stem cells: a systematic review [PDF]

Farideh Kamarehei
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Unveiling the clinical impact of plasma-only mutations in non-small cell lung cancer: a Korean multicenter experience. [PDF]

Transl Lung Cancer Res
Lee JW, Choi YJ, Kim JS, Kang EJ, Ahn MS, Kim YJ, Yi SY, Lim S, Lee JY, Kim JW, Shin SW, Kim YH.   +11 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies. [PDF]

Bone Res
Del Toro Runzer C, Balmayor ER, van Griensven M.   +2 more
europepmc   +1 more source

Tissue-engineered and cell-based therapies for cartilage defects [PDF]

Polina A. Golubinskaya, ES Ruchko, Arina S. Pikina, Olga Lebedeva, Artem V. Eremeev   +4 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source