Advanced therapies for the treatment of hemophilia: future perspectives [PDF]
, 2012 Monogenic diseases are ideal candidates for treatment by the emerging advanced therapies, which are capable of correcting alterations in protein expression that result from genetic mutation.
Gaban, Aline S. +2 more
core +4 more sources
Monitoring wound healing of burn in rat model using human Wharton’s jelly mesenchymal stem cells containing cGFP integrated by lentiviral vectors [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Human Wharton’s Jelly mesenchymal stem cells (hWMSCs) are undifferentiated cells commonly used in regenerative medicine. The aim of this study was to develop a reliable tool for tracking hWMSCs when utilized as therapeutics in burnt ...
Mohammad Reza Pourfath +5 more
doaj +1 more source
Adipose tissue derived mesenchymal stem cell transplantation in the treatment of ischemia/reperfusion induced acute kidney injury in rats. Application route and therapeutic window [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell Methods: 16-week-old Wistar rats (n=72)
Betânia Souza Monteiro +9 more
doaj +1 more source
Effects of rabbit pinna-derived blastema cells on tendon healing [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Tendon healing is substantially slow and often associated with suboptimal repair. Cell therapy is one of the promising methods to improve tendon repair.
Nooshin Ghayemi +4 more
doaj +1 more source
Transplantation of human immature dental pulp stem cell in dogs with chronic spinal cord injury [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases.
Matheus Levi Tajra Feitosa +8 more
doaj +1 more source
Potential Cell-Based and Cell-Free Therapy for Patients with COVID-19
Cells, 2022 Since it was first reported, the novel coronavirus disease 2019 (COVID-19) remains an unresolved puzzle for biomedical researchers in different fields. Various treatments, drugs, and interventions were explored as treatments for COVID.
Marselina Irasonia Tan +7 more
doaj +1 more source
Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy [PDF]
, 2017 Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease; the identification of novel targets and development of effective treatment strategies are urgently needed to improve patient outcomes.
Olson, Michael F. +4 more
core +1 more source
Regulatory Framework for Advanced Therapy Medicinal Products in Europe and United States
Frontiers in Pharmacology, 2019 Advanced therapy medicinal products (ATMPs) are a fast-growing field of innovative therapies. The European Union (EU) and the United States (US) are fostering their development.
Carolina Iglesias-Lopez +5 more
doaj +1 more source
Cell-derived extracellular vesicles and membranes for tissue repair
Journal of Nanobiotechnology, 2021 Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the ...
Yuan Ding +7 more
doaj +1 more source
Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa [PDF]
European Cells & Materials, 2018 The combination of gene therapy and tissue engineering is one of the most promising strategies for the treatment of recessive dystrophic epidermolysis bullosa (RDEB).
A Dakiw Piaceski +8 more
doaj +1 more source