Results 141 to 150 of about 1,959,228 (334)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mouse N2a Neuroblastoma Assay: Uncertainties and Comparison with Alternative Cell-Based Assays for Ciguatoxin Detection. [PDF]

Mar Drugs, 2023
Raposo-Garcia S, Cao A, Costas C, Louzao MC, Vilariño N, Vale C, Botana LM.   +6 more
europepmc   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays. [PDF]

Bioeng Transl Med, 2023
Kasper SH, Otten S, Squadroni B, Orr-Terry C, Kuang Y, Mussallem L, Ge L, Yan L, Kannan S, Verma CS, Brown CJ, Johannes CW, Lane DP, Chandramohan A, Partridge AW, Roberts LR, Josien H, Therien AG, Hett EC, Howell BJ, Peier A, Ai X, Cassaday J.   +22 more
europepmc   +1 more source

Cell-Based hERG Channel Inhibition Assay in High-Throughput Format

, 2022
Jinghua Zhao, Menghang Xia
openalex   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs

STAR Protocols
Summary: Mitochondrial respirometry provides a detailed assessment of oxygen consumption within the electron transport system, yet methods detailing respiration from non-invasive samples remain limited.
Tina R. Ram, Chunlong Mu, Jaclyn C. Campbell, Sarah J. MacEachern, Jane Shearer   +4 more
doaj   +1 more source

Small Molecules Targeting 3C Protease Inhibit FMDV Replication and Exhibit Virucidal Effect in Cell-Based Assays. [PDF]

Viruses, 2023
Theerawatanasirikul S, Lueangaramkul V, Pantanam A, Mana N, Semkum P, Lekcharoensuk P.   +5 more
europepmc   +1 more source

TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer. [PDF]

, 2019
Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB)
Conroy, Jeffrey, Fong, Lawrence, Looney, Timothy John, Lowman, Geoffrey, Morrison, Carl, Oh, David, Topacio-Hall, Denise, Zhang, Li   +7 more
core  

MitoToxy assay: A novel cell-based method for the assessment of metabolic toxicity in a multiwell plate format using a lactate FRET nanosensor, Laconic

, 2019
Yasna Contreras‐Baeza, Sebastián Ceballo, Robinson Arce‐Molina, Pamela Y. Sandoval, Karin Alegría, L. Felipe Barros, Alejandro San Martín   +6 more
openalex   +1 more source