Results 241 to 250 of about 4,481,323 (329)

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Induced pluripotent stem cell-based assays recapture multiple properties of human astrocytes. [PDF]

J Cell Mol Med
Nonaka H, Kondo T, Suga M, Yamanaka R, Sagara Y, Tsukita K, Mitsutomi N, Homma K, Saito R, Miyoshi F, Ohzeki H, Okuyama M, Inoue H.   +12 more
europepmc   +1 more source

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes. [PDF]

SLAS Discov, 2022
Kassner M, Eaton JB, Tang N, Petit JL, Meurice N, Yin HH, Whiteaker P.   +6 more
europepmc   +1 more source

Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay [PDF]

, 2006
Mark E Shaneyfelt, Anna Burke, Joel W. Graff, Mark A. Jutila, Michele E. Hardy   +4 more
openalex   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors. [PDF]

Int J Mol Sci
Wu Y, Jensen N, Rossner MJ, Wehr MC.
europepmc   +1 more source

Detection of MOG-IgG in Clinical Samples by Live Cell-Based Assays: Performance of Immunofluorescence Microscopy and Flow Cytometry. [PDF]

Front Immunol, 2021
Marchionatti A, Hansel G, Avila GU, Sato DK.   +3 more
europepmc   +1 more source

A High-Throughput Cell-Based Assay to Identify Specific Inhibitors of Transcription Factor AP-1 [PDF]

, 2006
Katie M. Ruocco, Ekaterina I. Goncharova, Matthew R. Young, Nancy H. Colburn, James B. McMahon, Curtis J. Henrich   +5 more
openalex   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Establishing a Relationship between In Vitro Potency in Cell-Based Assays and Clinical Efficacious Concentrations for Approved GLP-1 Receptor Agonists. [PDF]

Pharmaceutics
Boianelli A, Nordell P, Earl J, Naylor J, Hornigold D, Jansson Löfmark R, Sundqvist M.   +6 more
europepmc   +1 more source