Results 251 to 260 of about 4,481,323 (329)

A Novel Cell-Based Assay for G-Protein-Coupled Receptor–Mediated Cyclic Adenosine Monophosphate Response Element Binding Protein Phosphorylation [PDF]

, 2006
Julie V. Selkirk, Lisa Nottebaum, Ian C. Ford, Mark Santos, Siobhan Malany, Alan C. Foster, Sandra Lechner   +6 more
openalex   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro

STAR Protocols
Summary: OXCT1 acts as a succinyltransferase to promote serine beta-lactamase-like protein (LACTB) K284 succinylation. Here, we present a protocol for detecting OXCT1-mediated LACTB succinylation levels and sites.
Wenhao Ma, Yuchen Sun, Huafeng Zhang
doaj  

Functional characterization of SORL1 variants in cell-based assays to investigate variant pathogenicity. [PDF]

Philos Trans R Soc Lond B Biol Sci
Fazeli E, Fazeli E, Fojtík P, Holstege H, Andersen OM.   +4 more
europepmc   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Protocol for in vitro co-culture, proliferation, and cell cycle analyses of patient-derived leukemia cells

STAR Protocols
Summary: Leukemia niche impacts quiescence; however, culturing patient-derived samples ex vivo is technically challenging. Here, we present a protocol for in vitro co-culture of patient-derived xenograft acute lymphoblastic leukemia (PDX-ALL) cells with ...
Jessica Parker, Sean Hockney, Carly Knill, David McDonald, Andrew Filby, Deepali Pal   +5 more
doaj  

Selective Elimination and Rationalization of Cell-based Assays in Deceased Donor Kidney Transplant Crossmatching. [PDF]

Transplant Direct
Khalili M, Famure O, Minkovich M, Tinckam KJ, Kim SJ.   +4 more
europepmc   +1 more source

Cell-based assays to identify novel retinoprotective agents. [PDF]

MethodsX, 2020
Bullock J, Pagan-Mercado G, Becerra SP.
europepmc   +1 more source

A study comparing variable number of tandem repeat (VNTR) loci-analysis and short tandem repeat (STR)-based assay in the assessment of chimaerism post allogeneic stem cell transplant and prediction of remission/relapse [PDF]

, 2006
Mickey Koh, Gee‐Fung How, Mickey Koh, Wai Fun Tan, Lay Cheng Lim, L.P. Koh, Seang-Beng Tan   +6 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source