Results 221 to 230 of about 2,936,501 (309)

Purification of post-transcriptionally modified tRNAs for enhanced cell-free translation systems. [PDF]

Nucleic Acids Res
Kalb EM, Alejo JL, Dias-Fields L, Knudson I, Davisson JA, Maldonado E, Chattrakun K, Lin S, Lee JY, He T, Schepartz A, Zhang S, Blanchard SC, Engelhart AE, Adamala KP.   +14 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A cell free system to study synthesis and transport of cytoplasmically translated mitochondiral proteins [PDF]

, 1977
Bandlow, Wolfhard, Kaudelitz, F., Korb, Harald, Neupert, Walter, Schweyen, R. J., Wolf, K., Zimmermann, Richard   +6 more
core  

Safety and Efficacy of Intra-articular Cell-Free Fat Extract Injection in Patients With Symptomatic Knee Osteoarthritis. [PDF]

Orthop J Sports Med
Xie K, Jia Z, Sun L, Wu J, Jiang X, Wang L, Ai S, Yu Z, Zhang W, Liu C, Yu Z, Yan M.   +11 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Use of cell-free DNA in early detection of lung cancer: a proof-of concept study. [PDF]

BMC Cancer
White LL, Maiyani M, Quintana LM, Powers JD, Nichols LE, Dollar B, Bedoy R, Martinez AE, Feigelson HS.   +8 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Cell-free transcriptomic profiles and mechanism insights in female androgenetic alopecia. [PDF]

Clin Transl Med
Jia L, Lu M, Deng S, Jin Y, Zhao C, Luo R, Zhu Y, Li Z, An Z, Jiang H, Li Y.   +10 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source