Results 231 to 240 of about 10,893,804 (303)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Epigenomic modifications define chromatin states to regulate cell-free DNA fragmentomics. [PDF]

Nat Commun
Gong F, Pan Y, Lin H, An Y, Yang M, Liu X, Bai Y, Zhang Z, Tang B, Zhang K, Zhao X, Zhao Y, Du C, Shen X, Sun K.   +14 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Utility of cell-free DNA in diagnosing tuberculous pleurisy: A systematic review and meta-analysis protocol. [PDF]

PLoS One
Shen Y, Du K, Ling Y, Yao L.
europepmc   +1 more source

A Very Hairy Case: Marked Leukocytosis in Hairy Cell Leukaemia

eJHaem
Stephanie Juané Kennedy, Anne‐Cecilia vanMarle   +1 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Improving cell-free metabolism through direct integration of artificial respiratory chains. [PDF]

Proc Natl Acad Sci U S A
Jarman OD, Bohra N, Claus P, Paczia N, Erb TJ.   +4 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Advancing Sports Injury Treatment Through Cell-Free MSC-Based Therapies: A Narrative Review. [PDF]

Muscles
Abuarqoub D, Abuarqoub AH, Emad M, Ellauzi MF.   +3 more
europepmc   +1 more source