Results 31 to 40 of about 380,699 (255)

Non-invasive prenatal testing of trisomy 18 by an epigenetic marker in first trimester maternal plasma. [PDF]

PLoS ONE, 2013
BACKGROUND:Quantification of cell-free fetal DNA by methylation-based DNA discrimination has been used in non-invasive prenatal testing of fetal chromosomal aneuploidy. The maspin (Serpin peptidase inhibitor, clade B (ovalbumin), member 5; SERPINB5) gene,
Da Eun Lee, Shin Young Kim, Ji Hyae Lim, So Yeon Park, Hyun Mee Ryu   +4 more
doaj   +1 more source

Cell‐free fetal DNA in celomic fluid

Ultrasound in Obstetrics & Gynecology, 2008
Ultrasound Obstet ...
Makrydimas, G., Gerovassili, A., Sotiriadis, A., Kavvadias, A., Nicolaides, K. H.   +4 more
openaire   +4 more sources

Cell-Free Fetal DNA Is Not Present in Plasma of Nonpregnant Mothers [PDF]

Clinical Chemistry, 2004
Fetal DNA sequences are present in the plasma of pregnant women (1) and can be studied to determine fetal sex(1) and RhD type (2). Unlike fetal cells, fetal cell-free DNA is cleared rapidly from plasma after delivery (3), with a half-life of 16–28 min. Even when clearance is slowed, as in preeclampsia (4), the mean half-life for clearance of fetal DNA ...
Rijnders, Robbert J. P., Christiaens, Godelieve C. M. L., Soussan, Aicha Ait, van der Schoot, C. Ellen   +3 more
openaire   +3 more sources

Implementing prenatal diagnosis based on cell-free fetal DNA: accurate identification of factors affecting fetal DNA yield.

PLoS ONE, 2011
ObjectiveCell-free fetal DNA is a source of fetal genetic material that can be used for non-invasive prenatal diagnosis. Usually constituting less than 10% of the total cell free DNA in maternal plasma, the majority is maternal in origin.
Angela N Barrett, Bernhard G Zimmermann, Darrell Wang, Andrew Holloway, Lyn S Chitty   +4 more
doaj   +1 more source

An online tool for fetal fraction prediction based on direct size distribution analysis of maternal cell-free DNA

BioTechniques, 2021
The discovery of circulating fetal DNA in the plasma of pregnant women has greatly promoted advances in noninvasive prenatal testing. Screening performance is enhanced with higher fetal fraction and analysis of samples whose fetal DNA fraction is lower ...
Luca Bedon, Josef Vuch, Simeone Dal Monego, Germana Meroni, Vanna Pecile, Danilo Licastro   +5 more
doaj   +1 more source

Detection of short tandem repeats at 5 loci and amelogenin with cell-free fetal DNA as a specimen in the development of prenatal paternity diagnostic tests

Egyptian Journal of Forensic Sciences, 2018
Introduction A prenatal paternity test is one widely-used method of determining the paternity of an unborn child. Such tests using chorionic villus or amniocentesis may increase the risk of harm to both mother and foetus.
Agung Sosiawan, Dadik Raharjo, Indah Nuraini, Nadia Kartikasari, Alexander Patera Nugraha, Muhammad Dimas Aditya Ari   +5 more
doaj   +1 more source

Quantity of total cell free and cell free fetal DNA in pregnancies with no complications and with preeclampsia [PDF]

Orvosi Hetilap, 2010
A plazmában keringő szabad DNS minőségi és mennyiségi vizsgálata mint a praenatalis diagnosztika lehetséges eszköze egy évtizedes múltra tekint vissza. Az általunk végzett vizsgálat célja az összes szabad DNS, valamint szabad magzati DNS mennyiségének vizsgálata volt szövődménymentes, illetve praeeclampsiával szövődött terhességek esetén.Módszerek:A ...
Levente, Lázár, Bálint, Nagy, Attila, Molvarec, János, Rigó   +3 more
openaire   +2 more sources

The effect of abnormal placentation on maternal serum fetal fraction of cell-free DNA

Journal of Perinatal Medicine, 2023
Abnormal placentation may affect the maternal serum fraction of cell-free fetal DNA (fetal fraction) determined as part of non-invasive prenatal screening (NIPS). This study aimed to assess whether the fetal fraction can predict placenta accreta spectrum
Rodriguez Marcella, Smith Erica L., Silva Lauren M., Gultekin-Elbir Elif Esra, Tetla Ryan, Genc Mehmet Rifat   +5 more
doaj   +1 more source

Relevance of Invasive Testing in Era of Non-Invasive Testing for Prenatal Chromosomal Abnormalities

Gynecology Obstetrics & Reproductive Medicine, 2022
Prenatal screening for chromosomal abnormalities has two components i.e. prenatal screening (maternal serum screening and cell-free fetal DNA screening) and prenatal diagnosis (chorionic villus sampling, amniocentesis, and cordocentesis).
Abhijeet Kumar, Madhusudan Dey, Devendra Arora   +2 more
doaj   +1 more source

Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy [PDF]

Journal of Human Genetics, 2016
The purpose of this noninvasive prenatal testing (NIPT) study was to compare the fetal fraction of singleton gestations by gestational age, maternal characteristics and chromosome-specific aneuploidies as indicated by z-scores. This study was a multicenter prospective cohort study. Test data were collected from women who underwent NIPT by the massively
Nobuhiro, Suzumori, Takeshi, Ebara, Takahiro, Yamada, Osamu, Samura, Junko, Yotsumoto, Miyuki, Nishiyama, Kiyonori, Miura, Hideaki, Sawai, Jun, Murotsuki, Michihiro, Kitagawa, Yoshimasa, Kamei, Hideaki, Masuzaki, Fumiki, Hirahara, Juan-Sebastian, Saldivar, Nilesh, Dharajiya, Haruhiko, Sago, Akihiko, Sekizawa   +16 more
openaire   +2 more sources