Results 71 to 80 of about 239,910 (281)

Automated design of protein-binding riboswitches for sensing human biomarkers in a cell-free expression system

Nature Communications, 2023
Cell-free genetically encoded biosensors have been developed to detect small molecules and nucleic acids, but they have yet to be reliably engineered to detect proteins.
Grace E. Vezeau, Lipika R. Gadila, Howard M. Salis   +2 more
doaj   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Double Stranded RNA in Human Seminal Plasma

Frontiers in Genetics, 2017
Recently, human semen was shown to contain cell-free nucleic acids, such as DNA, long single stranded RNA, and small RNAs–miRNA and piRNA. The RNAs have been suggested to have potential biological roles as communication molecules between cells and in the
Maxim V. Zagoskin, Maxim V. Zagoskin, Richard E. Davis, Dmitry V. Mukha   +3 more
doaj   +1 more source

New indicator of cellular ischemia in coronary slow-flow phenomenon: Cell-free DNA

Türk Kardiyoloji Derneği Arşivi, 2020
Objective: Coronary slow-flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to the distal vascular bed in at least 1 major epicardial coronary artery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in the blood
Mustafa Yolcu, Ali Dogan, Nuri Kurtoglu, Veysel Sabri Hancer, Mehmet Gürbüzel   +4 more
doaj   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Circulating Cell-Free Nucleic Acid Detection for Wuchereria bancrofti Infections

The Journal of Infectious Diseases
Abstract Human lymphatic filariasis (LF) is primarily caused by the helminth parasites Wuchereria bancrofti (Wb) and Brugia malayi (Bm). Detecting parasitic circulating cell-free nucleic acids (ccfDNA/ccfRNA) in plasma is a promising approach for detection of active infections.
Marisa Martinez Salazar, Paul Schaughency, Thomas B Nutman, Sasisekhar Bennuru   +3 more
openaire   +4 more sources

Circulating cell‐free mitochondrial DNA in diabetes mellitus: Current insights and unexplored frontiers

Journal of Diabetes Investigation
The role and significance of circulating cell‐free mitochondrial DNA (ccf‐mtDNA)—small fragments of mitochondrial DNA present in plasma—are becoming increasingly clear in various diseases.
Mohammadreza Akbari, Fatemeh Masjedi, Mohammad Nekooeian, Mahintaj Dara, Jamshid Roozbeh   +4 more
doaj   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Mécanismes de la peroxydation lipidique et des anti-oxydations

Oléagineux, Corps gras, Lipides, 2006
Lipid peroxidation is a general phenomenon which takes place in foods as well as in cellular membranes and lipoproteins. It leads to oxidative dammages with consequences to food preservation and to the development of various diseases.
Cillard Josiane, Cillard Pierre
doaj   +1 more source