Results 151 to 160 of about 13,230,245 (270)

Enhancing the performance of a mutant pyrrolysyl-tRNA synthetase to create a highly versatile eukaryotic cell-free protein synthesis tool. [PDF]

Sci Rep, 2023
Schloßhauer JL, Zemella A, Dondapati SK, Thoring L, Meyer M, Kubick S.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Establishing a Klebsiella pneumoniae-Based Cell-Free Protein Synthesis System. [PDF]

Molecules, 2022
Yang C, Yang M, Zhao W, Ding Y, Wang Y, Li J.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Eukaryotic cell-free protein synthesis: Chassis diversification, system engineering, and emerging applications. [PDF]

Synth Syst Biotechnol
Tong S, Wang Y, Wang X, Jin X, Tan D, Wang Z, Lu Y.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

High-throughput mutational analysis of F₁-ATPase by integrated cell-free protein synthesis and single-molecule rotation assay. [PDF]

Protein Sci
Taguchi M, Oya T, Ueno H, Noji H.
europepmc   +1 more source

Designing of an extract production protocol for industrial application of cell-free protein synthesis technology: Building from a current best practice to a quality by design approach. [PDF]

Eng Biol, 2023
Melinek BJ, Tuck J, Probert P, Branton H, Bracewell DG.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Phosphoserine as an Alternative Energy Source for <i>E. coli</i> Cell-Free Protein Synthesis with Increased Yield and Prolonged Activity. [PDF]

ACS Synth Biol
Ackerman S, Fink Y, Habib Y, Cohen-Karni D, Adir O, Chen G, Richtman Y, Siquenique S, Levi M, Shklover J, Sarmento B, Schroeder A.   +11 more
europepmc   +1 more source