Results 161 to 170 of about 13,230,245 (270)

Cell-Free Protein Synthesis for the Screening of Novel Azoreductases and Their Preferred Electron Donor. [PDF]

Chembiochem, 2022
Rolf J, Ngo ACR, Lütz S, Tischler D, Rosenthal K.   +4 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Impact of Reducing Agents on Protein Synthesis in a Reconstituted Cell-Free Protein Synthesis System. [PDF]

ACS Synth Biol
Fuse-Murakami T, Terazawa S, Gondhalekar R, Ito S, Miyawaki S, Mizukami Y, Salgado WP, Yang Z, Fujishima K, Kanamori T.   +9 more
europepmc   +1 more source

Accessible light-controlled knockdown of cell-free protein synthesis using phosphorothioate-caged antisense oligonucleotides. [PDF]

Commun Chem, 2023
Hartmann D, Booth MJ.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Artificial cells with liquid-liquid phase separation-regulated cell-free protein synthesis. [PDF]

Proc Natl Acad Sci U S A
Fan D, Liang K, Wu B, Chen MW, Sun C, Sun L, Zhang Y, Du Y.   +7 more
europepmc   +1 more source

Bcl-xL Is Spontaneously Inserted into Preassembled Nanodiscs and Stimulates Bax Insertion in a Cell-Free Protein Synthesis System. [PDF]

Biomolecules, 2023
Rouchidane Eyitayo A, Boudier-Lemosquet A, Chaignepain S, Priault M, Manon S.   +4 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Cell-free Protein Synthesis Extract Preparation Methods

, 2013
My ORCA project proposed to test and optimize various low capital cost cell lysis methods, while leaving the internal cell machinery intact and viable for cell-free protein synthesis research. Our cells of interest were a strain of the bacterium E. coli,
Holland, Troy, Bundy, Dr. Brad
core  

An AI-driven workflow for the accelerated optimization of cell-free protein synthesis. [PDF]

iScience
Khalil MM, Elsawah A, Hoang AN, Faulon JL, Panthu B, Hérisson J.   +5 more
europepmc   +1 more source