Results 171 to 180 of about 1,006,135 (293)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cell-Free Protein Synthesis for the Screening of Novel Azoreductases and Their Preferred Electron Donor. [PDF]

Chembiochem, 2022
Rolf J, Ngo ACR, Lütz S, Tischler D, Rosenthal K.   +4 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Eukaryotic cell-free protein synthesis: Chassis diversification, system engineering, and emerging applications. [PDF]

Synth Syst Biotechnol
Tong S, Wang Y, Wang X, Jin X, Tan D, Wang Z, Lu Y.   +6 more
europepmc   +1 more source

Bcl-xL Is Spontaneously Inserted into Preassembled Nanodiscs and Stimulates Bax Insertion in a Cell-Free Protein Synthesis System. [PDF]

Biomolecules, 2023
Rouchidane Eyitayo A, Boudier-Lemosquet A, Chaignepain S, Priault M, Manon S.   +4 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Impact of Reducing Agents on Protein Synthesis in a Reconstituted Cell-Free Protein Synthesis System. [PDF]

ACS Synth Biol
Fuse-Murakami T, Terazawa S, Gondhalekar R, Ito S, Miyawaki S, Mizukami Y, Salgado WP, Yang Z, Fujishima K, Kanamori T.   +9 more
europepmc   +1 more source

Accessible light-controlled knockdown of cell-free protein synthesis using phosphorothioate-caged antisense oligonucleotides. [PDF]

Commun Chem, 2023
Hartmann D, Booth MJ.
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Artificial cells with liquid-liquid phase separation-regulated cell-free protein synthesis. [PDF]

Proc Natl Acad Sci U S A
Fan D, Liang K, Wu B, Chen MW, Sun C, Sun L, Zhang Y, Du Y.   +7 more
europepmc   +1 more source