Results 101 to 110 of about 9,966,852 (260)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The development of synthetic biology: A patent analysis

, 2022
S.209-220In the past decades, synthetic biology has gained interest regarding research and development efforts within the biotechnology domain.
Reiß, T., Doren, D. van, Königstein, S.   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Transnational Governance of Synthetic Biology: Scientific uncertainty, cross-borderness and the ‘art’ of governance. For the Royal Society Science Policy Centre (UK). [PDF]

, 2011
Synthetic biology is a new field of research that aims to 'make biology easier to engineer'. Some claim that it could revolutionise biotechnology to deliver applications for the energy, medical and agricultural sectors. However there are concerns about
Zhang, Joy Yueyue, Rose, Nikolas, Rose, N., Marris, C., Marris, Claire, Zhang, J., Zhang, Joy Y.   +6 more
core  

Sigma factor-mediated tuning of bacterial cell-free synthetic genetic oscillators [PDF]

, 2018
Cell-free transcription-translation provides a simplified prototyping environment to rapidly design and study synthetic networks. Despite the presence of a well characterized toolbox of genetic elements, examples of genetic networks that exhibit complex ...
Tom F. A. de Greef (1516579), Pascal A. Pieters, Greef, TFA Tom de, Pieters, PA Pascal, Bob van Sluijs (4638499), de Greef, T.F.A., Huck, Wilhelm T.S., Ardjan J. van der Linden (672005), Emilien Dubuc, Pascal A. Pieters (672006), Maaruthy Yelleswarapu, Emilien Dubuc (5988659), Ardjan J. van der Linden, Tom F. A. de Greef, Maaruthy Yelleswarapu (2823188), Huck, Wilhelm T S, Bob van Sluijs, Dubuc, E, Dubuc, E., Linden, AJ Ardjan van der, Yelleswarapu, Maaruthy, Wilhelm T. S. Huck (1292637), van der Linden, A.J., Pieters, P.A., Wilhelm T. S. Huck   +24 more
core   +2 more sources

Yeast knockout library allows for efficient testing of genomic mutations for cell-free protein synthesis

Synthetic and Systems Biotechnology, 2016
Cell-free protein synthesis (CFPS) systems from crude lysates have benefitted from modifications to their enzyme composition. For example, functionally deleting enzymes in the source strain that are deleterious to CFPS can improve protein synthesis ...
Jennifer A. Schoborg, Lauren G. Clark, Alaksh Choudhury, C. Eric Hodgman, Michael C. Jewett   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Pictures of Synthetic Biology [PDF]

, 2009
This article is concerned with the representation of Synthetic Biology in the media and by biotechnology experts. An analysis was made of German-language media articles published between 2004 and 2008, and interviews with biotechnology-experts at the ...
Seiringer, Alexandra, Cserer, Amelie, Alexandra Seiringer, Amelie Cserer   +3 more
core   +1 more source

Synthetic biology: From the first synthetic cell to see its current situation and future development

, 2011
Synthetic biology is an emerging field, which, since its birth, has shown great value and potential in many fields including medicine, energy, environment and agriculture. It is also important for the study of the origin and evolution of life.
Chang SuHua, Zhang LiuYan, Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China., Wang Jing   +3 more
core   +1 more source

Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists

Nature Communications
Synthetic biology allows us to reuse, repurpose, and reconfigure biological systems to address society’s most pressing challenges. Developing biotechnologies in this way requires integrating concepts across disciplines, posing challenges to educating ...
Ashty S. Karim, Dylan M. Brown, Chloé M. Archuleta, Sharisse Grannan, Ludmilla Aristilde, Yogesh Goyal, Josh N. Leonard, Niall M. Mangan, Arthur Prindle, Gabriel J. Rocklin, Keith J. Tyo, Laurie Zoloth, Michael C. Jewett, Susanna Calkins, Neha P. Kamat, Danielle Tullman-Ercek, Julius B. Lucks   +16 more
doaj   +1 more source