Results 161 to 170 of about 2,292,973 (264)

Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort. [PDF]

Synth Syst Biotechnol, 2020
Spice AJ, Aw R, Bracewell DG, Polizzi KM.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Evidence That Phosphorylation of the α-Subunit of eIF2 Does Not Essentially Inhibit mRNA Translation in Wheat Germ Cell-Free System. [PDF]

Front Plant Sci, 2020
Zhigailov AV, Alexandrova AM, Nizkorodova AS, Stanbekova GE, Kryldakov RV, Karpova OV, Polimbetova NS, Halford NG, Iskakov BK.   +8 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System. [PDF]

Bioengineering (Basel)
Shivakumar T, Clark J, Goode A, Anyanwu VE, Williams PM.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A broad spectrum Shigella vaccine based on VirG_53-353 multiepitope region produced in a cell-free system. [PDF]

NPJ Vaccines
Desalegn G, Abrahamson C, Ross Turbyfill K, Pill-Pepe L, Bautista L, Tamilselvi CS, Dunn D, Kapoor N, Sullinger B, Herrera M, Oaks EV, Fairman J, Pasetti MF.   +12 more
europepmc   +1 more source

SMIM1, carrier of the Vel blood group, is a tail-anchored transmembrane protein and readily forms homodimers in a cell-free system. [PDF]

Biosci Rep, 2020
Nylander A, Leznicki P, Vidovic K, High S, Olsson ML.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Feeder-cell-free system for <i>ex vivo</i> production of natural killer cells from cord blood hematopoietic stem and progenitor cells. [PDF]

Front Immunol
Martin Corredera M, Paillet J, Gaudeaux P, Blein T, Sadek H, Rault P, Berriche A, Roche-Naude J, Lagresle-Peyrou C, Soheili TS, André I, Moirangthem RD, Negre O.   +12 more
europepmc   +1 more source