Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Sensitivity analysis applied to the multi-objective optimization of a MCFC hybrid plant [PDF]
, 2012 In this paper, the multi-objective optimization of a molten carbonate fuel cell (MCFC) based hybrid plant fueled with landfill gas is performed. System operation is significantly affected by off-design conditions.
Adriano Sciacovelli +27 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
A permeabilized cell model for studying cytokinesis using mammalian tissue culture cells. [PDF]
, 1980 PtK1 cells lysed late in cell division in a medium containing the nonionic detergent Brij 58 and polyethylene glycol with continue to undergo cleavage after lysis.
CANDE, W. Zacheus
core
Electrical permittivity and resistivity time lapses of multiphase DNAPLs in a lab test [PDF]
, 2014 Dense Non-Aqueous Phase Liquids (DNAPLs) induce variation in electromagnetic characteristics of the ground e.g. electric permittivity and resistivity.
Orlando, Luciana, Renzi, Beatrice
core +2 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Autologous T-Cell-Free Antigen Presentation System Unveils hCMV-Specific NK Cell Response
CellsNK cells play a decisive role in controlling hCMV infection by combining innate and adaptive-like immune reactions. The hCMV-derived VMAPRTLFL (LFL) peptide is a potent activator of NKG2C+ NK cells.
Maria O. Ustiuzhanina +5 more
doaj +1 more source
Viruses do replicate in cell-free systems [PDF]
Proceedings of the National Academy of Sciences, 2012 Klingeborn et al. (1) reported a systematic study of the infectivity of transmissible spongiform encephalopathy (TSE) infectious agent generated de novo in cell-free reactions. They convincingly demonstrated the generation of new TSE infectivity in reactions primed by infected brain homogenates.
openaire +2 more sources
Experiments and operational procedures for developing germ-free seeds, seedlings, plants, tissues and cell lines for the Lunar Receiving Laboratory Final report [PDF]
Germ-free seeds, seedlings, plants, tissues, and cell lines for lunar receiving laboratory, including algal and vascular plant ...
Venketeswaren, S.
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source