Results 121 to 130 of about 116,742,798 (255)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion

, 2017
Cellular blebbing, caused by local alterations in cellsurface tension, has been shown to increase the invasiveness of cancer cells. However, the regulatory mechanisms balancing cell-surface dynamics and bleb formation remain elusive.
Madlen Hubert, Vidal-Quadras, Maite, Larsson, Elin, Richard Lundmark, Jeanette Blomberg, Blomberg, Jeanette,, Hubert, Madlen, Hubert, Madlen,, Mikkel Roland Holst, Blomberg, Jeanette, Holst, Mikkel Roland, Holst, Mikkel Roland,, Song, Jie, Jie Song, Landström, Maréne, Lundmark, Richard, Maite Vidal-Quadras, Elin Larsson, Vidal-Quadras, Maite,, Landström, Maréne,, Lundborg, Magnus, Magnus Lundborg, Song, Jie,, Maréne Landström, Lundmark, Richard,, Larsson, Elin,, Lundborg, Magnus,   +26 more
core   +1 more source

3D-printing magnesium-polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures. [PDF]

J Nanobiotechnology, 2021
Zhang W, Zhao W, Li Q, Zhao D, Qu J, Yuan Z, Cheng Z, Zhu X, Zhuang X, Zhang Z.   +9 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision.

Reactive oxygen species (ROS) influence cell proliferation and fate decisions by oxidizing cysteine residues (S-sulfenylation) of proteins, but specific targets and underlying regulatory mechanisms remain poorly defined.
Coupe, D, Yu, L, Böhlig, K, Zerjatke, T, Mansfeld, J, Vorhauser, J, Glauche, I, Choudhary, JS, Roumeliotis, TI, Leung, JK, Nadler, A   +10 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Study on the Influence of the Cell Structure on the Pressure Drop of Gasoline Particulate Filter

Atmosphere
The cell structure of a gasoline particulate filter (GPF) is made up of thousands of individual cells. Although the symmetric square cell structure of the GPF is commonly used internationally, several cell designs have been proposed to reduce the ...
Lishuan Huang, Chao He, Nan Yang, Jiaqiang Li, Yanlin Chen, Haisheng Yu, Dongge Wang, Yangyu Yao   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source