Results 111 to 120 of about 116,742,798 (255)

All brains are made of this: a fundamental building block of brain matter with matching neuronal and glial masses

Frontiers in Neuroanatomy, 2014
How does the size of the glial and neuronal cells that compose brain tissue vary across brain structures and species? Our previous studies indicate that average neuronal size is highly variable, while average glial cell size is more constant.
Bruno eMota, Suzana eHerculano-Houzel
doaj   +1 more source

AIM-CICs: an automatic identification method for cell-in-cell structures based on convolutional neural network. [PDF]

J Mol Cell Biol, 2022
Tang M, Su Y, Zhao W, Niu Z, Ruan B, Li Q, Zheng Y, Wang C, Zhang B, Zhou F, Wang X, Huang H, Shi H, Sun Q.   +13 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Accelerating aqueous electrolyte design with automated full-cell battery experimentation and Bayesian optimization

The integration of automation and data-driven methodologies offers a promising approach to accelerating materials discovery in energy storage research.
Berg, Erik J., Zhang, Leiting, Yik, Jackie,, Yik, Jackie T., Zhang, Leiting,, Berg, Erik J.,, Yik, Jackie, Sjölund, Jens, Hvarfner, Carl, Sjölund, Jens,   +9 more
core   +1 more source

Combining spatial and single-cell transcriptome data to analyze tertiary lymphoid structures in clear cell renal cell carcinoma reveals prognostic biomarkers

Journal of Translational Medicine
Background As the predominant and most aggressive subtype of renal cell carcinoma (RCC), clear cell RCC (ccRCC) represents the considerable heterogeneity present across RCC subtypes.
Xuechao Li, Pu Liu, Man Li, Yongzhu Zhou, Tianwei Li, Tao Yang, Jinkai Dong, Chengwei Fu, Yunping Zhu, Lijun Chen, Jie Ma, Wanlin Liu   +11 more
doaj   +1 more source

Fabrication of fully aligned self-assembled cell-laden collagen filaments for tissue engineering via a hybrid bioprinting process

Bioactive Materials
Cell-laden structures play a pivotal role in various tissue engineering applications, particularly in tissue restoration. Interactions between cells within bioprinted structures are crucial for successful tissue development and regulation of stem cell ...
JuYeon Kim, Hyeongjin Lee, Gyudo Lee, Dongryeol Ryu, GeunHyung Kim   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Environmentally dependent and independent control of 3D cell shape.

How cancer cells determine their shape in response to three-dimensional (3D) geometric and mechanical cues is unclear. We develop an approach to quantify the 3D cell shape of over 60,000 melanoma cells in collagen hydrogels using high-throughput stage ...
Dent, LG, Rowe-Brown, L, Maioli, V, Sparks, H, Munro, I, Arias-Garcia, M, Bakal, C, Butera, F, Bousgouni, V, Kumar, S, Dunsby, C, Curry, N, Jones, I   +12 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source