Results 91 to 100 of about 116,742,798 (255)

The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer

Journal of Translational Medicine, 2012
Background Advanced endometrial cancer often shows resistance to clinical chemotherapy although potencies of anticancer drugs in vitro are promising. The disparity suggests that in vivo microenvironments are not recapitulated by in vitro models used for ...
Chitcholtan Kenny, Sykes Peter H, Evans John J   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

, 2021
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the β ...
Rackham, Chloe, Lambert, C, Evans, Ian, Sancho, Rocio; id_orcid, Messal, Hendrik A., Jones, P, Hubber, Ella-louise, Messal, HA, Lambert, Christopher, Behrens, Axel, Heimberg, Harry, Hubber, E-L, Heimberg, H, Rackham, C, Jones, Peter; id_orcid, Evans, I, Gribben, C, Behrens, A, Gribben, Christopher, Sancho, R   +19 more
core   +1 more source

CHANGES OF CELL STRUCTURES OF HYDROBIONTS IN PATHOLOGY

Ветеринарная патология, 2016
Morphological and quantitative changes in the cells of the circulating fluids of aquatic organisms: hemolymph or blood in the pathology. Were investigated: Astacusastacus, Carassiusgibelio, Cyprinus carpio L, Ambystomamexicanum .
G. I. Pronina, N. U. Koryagina
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source

Effects of the unit-cell size and arrangement on the compressive behaviors of lattice structures in powder bed fusion additive manufacturing

Results in Materials
Lattice structures demonstrate a unique compressive behavior wherein the compressive strength increases and converges to a specific value as the number of unit-cell arrangements and overall dimensions of the lattice structure increase. In this study, the
Kwang-Min Park, Young-Sook Roh, Bong-Chun Lee   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

, 2020
Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating following transplantation and have recently advanced to clinical trials for Parkinson's disease (PD).
Kirik, Deniz,, Kirik, Deniz, Thompson, Lachlan H., Penna, Vanessa,, Hunt, Cameron P.J., de Luzy, Isabelle R.,, Hunt, Cameron P.J.,, Kauhausen, Jessica A., Gantner, Carlos W.,, Bye, Christopher R.,, Thompson, Lachlan H.,, Niclis, Jonathan C.,, Niclis, Jonathan C., Ermine, Charlotte M., Moriarty, Niamh, Bye, Christopher R., Gantner, Carlos W., de Luzy, Isabelle R., Penna, Vanessa, Parish, Clare L., Kauhausen, Jessica A.,, Parish, Clare L.,, Pouton, Colin W., Moriarty, Niamh,, Lund University., Pouton, Colin W.,, Ermine, Charlotte M.,   +26 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source