Results 71 to 80 of about 116,742,798 (255)

Single-Cell Visualization Deep in Brain Structures by Gene Transfer

Frontiers in Neural Circuits, 2020
A projection neuron targets multiple regions beyond the functional brain area. In order to map neuronal connectivity in a massive neural network, a means for visualizing the entire morphology of a single neuron is needed.
Sayaka Sugiyama, Junko Sugi, Tomoya Iijima, Xubin Hou   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

, 2019
Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human ...
Sundström, Anders, Čančer, Matko,, Garancher, Alexandra, Weishaupt, Holger, Falk, Anna,, Bergström, Tobias, Wechsler-Reya, Robert J., Tailor, Jignesh, Johansson, Fredrik K.,, Bergström, Tobias,, Sundström, Anders,, Wechsler-Reya, Robert J.,, Čančer, Matko, Holmberg Olausson, Karl, Holmberg Olausson, Karl,, Tailor, Jignesh,, Hutter, Sonja, Hutter, Sonja,, Essand, Magnus, Rosén, Gabriela, Weishaupt, Holger,, Falk, Anna, Johansson, Fredrik K., Rosén, Gabriela,, Essand, Magnus,, Garancher, Alexandra,   +25 more
core   +1 more source

PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment [PDF]

, 2016
Shigella flexneri, the pathogen responsible for bacillary dysentery, has evolved multiple strategies to control the inflammatory response. Here, we show that Shigella subverts the subcellular trafficking of the intercellular adhesion molecule-1 (ICAM-1),
Boal, Frédéric, Hélène Tronchère, Tronchére, Héléne,, Puhar, Andrea, Philippe J. Sansonetti, Bernard Payrastre, Kunduzova, Oksana,, Payrastre, Bernard,, Xuereb, Jean-Marie,, Puhar, Andrea,, Oksana Kunduzova, Xuereb, Jean-Marie, Tronchére, Héléne, Payrastre, Bernard, Boal, Frédéric,, Jean-Marie Xuereb, Sansonetti, Philippe J., Frédéric Boal, Sansonetti, Philippe J.,, Kunduzova, Oksana, Andrea Puhar   +20 more
core   +1 more source

Detecting global and local hierarchical structures in cell-cell communication using CrossChat

Nature Communications
Cell-cell communication (CCC) occurs across different biological scales, ranging from interactions between large groups of cells to interactions between individual cells, forming a hierarchical structure.
Xinyi Wang, Axel A. Almet, Qing Nie
doaj   +1 more source

Structural and Energetic Evidence Supports the Non-Covalent Phosphate Cyclization by the Class II Phospholipase D from Loxosceles intermedia

Toxins
Phospholipase D (PLD) enzymes from Loxosceles spider venom mediate envenomation pathology by cleaving phospholipid headgroups. We revisited the crystal structure of Loxosceles intermedia PLD (PDB: 3RLH) to evaluate two alternative mechanisms—covalent and
Carolina Gismene, José Fernando Ruggiero Bachega, Daniel Z. Doherty, Silvio Sanches Veiga, Raghuvir K. Arni, Jorge Enrique Hernández González   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Diversification of Cell Death and Immunity: Memento Mori.

, 2019
Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and
Legrand, AJ, Konstantinou, M, Goode, EF, Meier, P   +3 more
core   +1 more source

Nanoscale-Textured Tantalum Surfaces for Mammalian Cell Alignment

Micromachines, 2018
Tantalum is one of the most important biomaterials used for surgical implant devices. However, little knowledge exists about how nanoscale-textured tantalum surfaces affect cell morphology.
Hassan I. Moussa, Megan Logan, Kingsley Wong, Zheng Rao, Marc G. Aucoin, Ting Y. Tsui   +5 more
doaj   +1 more source