Results 81 to 90 of about 116,742,798 (255)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

, 2023
Tumor growth is driven by continued cellular growth and proliferation. Cyclin-dependent kinase 7's (CDK7) role in activating mitotic CDKs and global gene expression makes it therefore an attractive target for cancer therapies.
Bertoli, Cosetta, Lauring, Josh, Vuina, Karla, Bertomeu, Thierry, Sava, Georgina, Huard, Caroline, Meneguello, Leticia, Kriston-Vizi, Janos, Maizels, Rory J, Tyers, Mike, de Bruin, Robertus AM, Wilson, Gemma A, Coulombe-Huntington, Jasmin, Ali, Simak   +13 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Autocrine glutamate signaling drives cell competition in Drosophila.

Cell competition is an evolutionarily conserved quality control process that eliminates suboptimal or potentially dangerous cells. Although differential metabolic states act as direct drivers of competition, how these are measured across tissues is not ...
Soares, CC, Maresma, MF, Rizzo, A, Meier, P   +3 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Multiplexed stimulated emission depletion nanoscopy (mSTED) for 5-color live-cell long-term imaging of organelle interactome

Opto-Electronic Advances
Stimulated emission depletion microscopy (STED) holds great potential in biological science applications, especially in studying nanoscale subcellular structures.
Yuran Huang, Zhimin Zhang, Wenli Tao, Yunfei Wei, Liang Xu, Wenwen Gong, Jiaqiang Zhou, Liangcai Cao, Yong Liu, Yubing Han, Cuifang Kuang, Xu Liu   +11 more
doaj   +1 more source

Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell–Cell Junctions

Frontiers in Cell and Developmental Biology, 2019
Cell–cell adhesion plays a key role in the maintenance of the epithelial barrier and apicobasal cell polarity, which is crucial for homeostasis. Disruption of cell–cell adhesion is a hallmark of numerous pathological conditions, including invasive ...
Diana Schuhmacher, Jean-Marie Sontag, Jean-Marie Sontag, Estelle Sontag, Estelle Sontag   +4 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

, 2020
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive.
Jiang, Jue, Han, Meng, Wang, Yanwu, Zhang, Yingchi, Feng, Hui, Zhu, Xiaofan, Qing, Guoliang, Sun, Yonghua, Wu, Chao, Yue, Ming, Cai, Xiaolian, Jiang, Peng, Wang, Tianci, Li, Peng, Liu, Hudan, Su, Hexiu, Wang, Jingchao, Xiao, Wuhan   +17 more
core   +1 more source

SCW: building the whole-genome 3D structures based on extremely sparse single-cell Hi-C data

BMC Bioinformatics
Background The study of three-dimensional (3D) genome structures at the single-cell level is crucial for understanding cell-to-cell variability. However, it is challenging to reconstruct the 3D structures of the whole genome based on single-cell Hi-C ...
Hao Zhu, Tong Liu, Bishal Shrestha, Zheng Wang   +3 more
doaj   +1 more source