Results 61 to 70 of about 653,749 (210)

Cell-to-cell communication circuits: quantitative analysis of synthetic logic gates

Frontiers in Physiology, 2012
One of the goals in the field of synthetic biology is the construction of cellular computation devices that could function in a manner similar to electronic circuits.
Marta eHoffman-Sommer, Adriana eSupady, Edda eKlipp   +2 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Future research directions and applications of artificial intelligence in tribology

Discover Mechanical Engineering
Artificial intelligence (AI) is transforming tribology by enabling the prediction and understanding of friction, wear, and lubrication at a higher level than conventional methods.
Amrinder Mehta, Hitesh Vasudev, S. Sabareshwaran, B. V. Suma, Jashanpreet Singh, Brijesh Prasad, Suresh Singh, Oda Tadese Katelo   +7 more
doaj   +1 more source

Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism

Frontiers in Endocrinology, 2015
It has been well established that, in the human adrenal gland, cortisol secretion is not only controlled by circulating corticotropin but is also influenced by a wide variety of bioactive signals, including conventional neurotransmitters and ...
Herve eLefebvre, Herve eLefebvre, Herve eLefebvre, Celine eDuparc, Celine eDuparc, Gaetan ePrevost, Gaetan ePrevost, Gaetan ePrevost, Jerome eBertherat, Jerome eBertherat, Estelle eLouiset, Estelle eLouiset   +11 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

SCInter: A comprehensive single-cell transcriptome integration database for human and mouse

Computational and Structural Biotechnology Journal
Single-cell RNA sequencing (scRNA-seq), which profiles gene expression at the cellular level, has effectively explored cell heterogeneity and reconstructed developmental trajectories.
Jun Zhao, Yuezhu Wang, Chenchen Feng, Mingxue Yin, Yu Gao, Ling Wei, Chao Song, Bo Ai, Qiuyu Wang, Jian Zhang, Jiang Zhu, Chunquan Li   +11 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

CELL TO CELL COMMUNICATION IN GLIOBLASTOMA PROGRESSION: INTRATUMORAL SYNAPSES?

IBRO Neuroscience Reports, 2023
María Losada-Pérez, Irene García-Ricote, Mamen Hernández García-Moreno, Sergio Casas Tintó   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source