Results 1 to 10 of about 82,919 (266)

Neuronal Cell Adhesion Molecules May Mediate Neuroinflammation in Autism Spectrum Disorder

Frontiers in Psychiatry, 2022
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by restrictive and repetitive behaviors, alongside deficits in social interaction and communication.
Madeline Eve, Josan Gandawijaya, Liming Yang, Asami Oguro-Ando   +3 more
doaj   +3 more sources

Spatiotemporal Control of Neuronal Remodeling by Cell Adhesion Molecules: Insights From Drosophila

Frontiers in Neuroscience, 2022
Developmental neuronal remodeling is required for shaping the precise connectivity of the mature nervous system. Remodeling involves pruning of exuberant neural connections, often followed by regrowth of adult-specific ones, as a strategy to refine ...
Hagar Meltzer, Hagar Meltzer, Oren Schuldiner, Oren Schuldiner   +3 more
doaj   +3 more sources

Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

iScience, 2022
Summary: Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its ...
Oguzhan Baltaci, Mikael Egebjerg Pedersen, Tessa Sherry, Ava Handley, Goda Snieckute, Wei Cao, Matilda Haas, Stuart Archer, Roger Pocock   +8 more
doaj   +1 more source

Two CIDP Variants Patients With Anti-Caspr1 Antibodies in South China

Frontiers in Immunology, 2022
Background and ObjectivesChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is considered an immune-mediated heterogeneous disease that involves both cellular and humoral immunity.
Chong Li, Hui Zheng, Chao Yuan, Yanran Li, Yafang Hu, Haishan Jiang   +5 more
doaj   +1 more source

Reciprocal interactions between cell adhesion molecules of the immunoglobulin superfamily and the cytoskeleton in neurons

Frontiers in Cell and Developmental Biology, 2016
Cell adhesion molecules of the immunoglobulin superfamily (IgSF) including the neural cell adhesion molecule (NCAM) and members of the L1 family of neuronal cell adhesion molecules play important functions in the developing nervous system by regulating ...
Vladimir eSytnyk, Iryna eLeshchyns'Ka
doaj   +1 more source

Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization

Frontiers in Cell and Developmental Biology, 2021
Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan, Kelsey E. Murphy, Patricia F. Maness   +2 more
doaj   +1 more source

Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis

Frontiers in Molecular Neuroscience, 2016
In view of important neurobiological functions of the cell adhesion molecule contactin-6 (Cntn6) that have emerged from studies on null-mutant mice and autism spectrum disorders (ASD) patients, we set out to examine pathways underlying functions of Cntn6
Amila Zuko, Amila Zuko, Asami Oguro-Ando, Asami Oguro-Ando, Harm Post, Harm Post, Renske L.R.E. Taggenbrock, Roland E. van Dijk, Maarten Altelaar, Maarten Altelaar, Albert J R Heck, Albert J R Heck, Alexander G Petrenko, Bert van der Zwaag, Yasushi Shimoda, R. Jeroen Pasterkamp, J. Peter H. Burbach   +16 more
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Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules

Cell Reports, 2022
Summary: Neurons in the developing brain express many different cell adhesion molecules (CAMs) on their surfaces. CAM-binding affinities can vary by more than 200-fold, but the significance of these variations is unknown.
Shuwa Xu, Alina P. Sergeeva, Phinikoula S. Katsamba, Seetha Mannepalli, Fabiana Bahna, Jude Bimela, S. Lawrence Zipursky, Lawrence Shapiro, Barry Honig, Kai Zinn   +9 more
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Synaptic Cell Adhesion Molecules in Alzheimer’s Disease

Neural Plasticity, 2016
Alzheimer’s disease (AD) is a neurodegenerative brain disorder associated with the loss of synapses between neurons in the brain. Synaptic cell adhesion molecules are cell surface glycoproteins which are expressed at the synaptic plasma membranes of ...
Iryna Leshchyns’ka, Vladimir Sytnyk
doaj   +1 more source

Scale invariant disordered nanotopography promotes hippocampal neuron development and maturation with involvement of mechanotransductive pathways

Frontiers in Cellular Neuroscience, 2016
The identification of biomaterials which promote neuronal maturation up to the generation of integrated neural circuits is fundamental for modern neuroscience.
Carsten Schulte, Carsten Schulte, Maddalena Ripamonti, Elisa Maffioli, Elisa Maffioli, Martino Alfredo Cappelluti, Martino Alfredo Cappelluti, Simona Nonnis, Luca Puricelli, Jacopo Lamanna, Claudio Piazzoni, Alessandro Podestà, Cristina Lenardi, Gabriella Tedeschi, Gabriella Tedeschi, Antonio Malgaroli, Paolo Milani   +16 more
doaj   +1 more source