Results 111 to 120 of about 271,506 (342)

Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]

, 2008
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core   +2 more sources

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily

Frontiers in Neuroscience, 2019
The adhesion G protein-coupled receptors latrophilins have been in the limelight for more than 20 years since their discovery as calcium-independent receptors for α-latrotoxin, a spider venom toxin with potent activity directed at neurotransmitter ...
Ana L. Moreno-Salinas, Monserrat Avila-Zozaya, Paul Ugalde-Silva, David A. Hernández-Guzmán, Fanis Missirlis, Antony A. Boucard   +5 more
doaj   +1 more source

Forces to Drive Neuronal Migration Steps

Frontiers in Cell and Developmental Biology, 2020
To establish and maintain proper brain architecture and elaborate neural networks, neurons undergo massive migration. As a unique feature of their migration, neurons move in a saltatory manner by repeating two distinct steps: extension of the leading ...
Takunori Minegishi, Naoyuki Inagaki
doaj   +1 more source

Exendin-4 induces cell adhesion and differentiation and counteracts the invasive potential of human neuroblastoma cells. [PDF]

PLoS ONE, 2013
Exendin-4 is a molecule currently used, in its synthetic form exenatide, for the treatment of type 2 diabetes mellitus. Exendin-4 binds and activates the Glucagon-Like Peptide-1 Receptor (GLP-1R), thus inducing insulin release.
Paola Luciani, Cristiana Deledda, Susanna Benvenuti, Roberta Squecco, Ilaria Cellai, Benedetta Fibbi, Ilaria Maddalena Marone, Corinna Giuliani, Giulia Modi, Fabio Francini, Gabriella Barbara Vannelli, Alessandro Peri   +11 more
doaj   +1 more source

Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]

, 2015
Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
core   +1 more source

Models of dynamic extraction of lipid tethers from cell membranes [PDF]

, 2010
When a ligand that is bound to an integral membrane receptor is pulled, the membrane and the underlying cytoskeleton can deform before either the membrane delaminates from the cytoskeleton or the ligand detaches from the receptor.
Cuvelier D, Lodish H, Morris C E, Sarah A Nowak, Tom Chou   +4 more
core   +1 more source

The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo*

Journal of Biological Chemistry, 2012
Background: The function and physiological substrates of BACE1 remain largely unknown. Results: Novel substrates for BACE1 were identified using large scale proteome analysis; L1 and CHL1 were validated in vivo.
Lujia Zhou, S. Barão, Mathias Laga, Katrijn Bockstael, M. Borgers, H. Gijsen, W. Annaert, D. Moechars, M. Mercken, Kris Gevaer, B. de Strooper   +10 more
semanticscholar   +1 more source

A soluble form of the F3 neuronal cell adhesion molecule promotes neurite outgrowth [PDF]

The Journal of cell biology, 1992
The F3 molecule is a member of the immunoglobulin superfamily anchored to membranes by a glycane-phosphatidylinositol, and is predominantly expressed on subsets of axons of the central and peripheral nervous system. In a previous paper (Gennarini, G., P. Durbec, A. Boned, G. Rougon, and C. Goridis. 1991. Neuron.
DURBEC P, GORIDIS C, ROUGON G., GENNARINI, Gianfranco   +3 more
openaire   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source