IgLON Cell Adhesion Molecules Are Shed from the Cell Surface of Cortical Neurons to Promote Neuronal Growth* [PDF]
Journal of Biological Chemistry, 2014 Background: Ectodomain shedding by the metalloproteinase family affects axon guidance and neurite outgrowth. Results: IgLON family members are metalloproteinase substrates that promote neurite outgrowth in a metalloproteinase-dependent manner. Conclusion:
Ricardo L. Sanz, G. Ferraro, A. Fournier
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Two antigenically related neuronal cell adhesion molecules of different specificities mediate neuron-neuron and neuron-glia adhesion. [PDF]
Proceedings of the National Academy of Sciences, 1984 Previous studies in this laboratory have led to the identification of the neural cell adhesion molecule, N-CAM, a homophilic ligand that mediates adhesion between neurons as well as between neurons and striated muscle precursors. By means of a similar immunological approach but with different assays, we have now identified a cell adhesion molecule on ...
M. Grumet, S. Hoffman, G. Edelman
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Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans
iScience, 2022 Summary: Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its ...
Oguzhan Baltaci +8 more
doaj +1 more source
NRCAM (neuronal cell adhesion molecule) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NRCAM (neuronal cell adhesion molecule), with data on DNA, on the protein encoded, and where the gene is implicated.
Janik, J, Czarnocka, B
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Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Synapses functionally connect neurons in the brain and mediate information processing relevant to all aspects of life. Among others, synaptic connections are enabled by cell adhesion molecules, which connect presynaptic and postsynaptic membranes by binding to each other via the synaptic cleft.
Földy, Csaba +5 more
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Regulation of Neuronal Cell Adhesion Molecule Expression by NF-κB [PDF]
Journal of Biological Chemistry, 2000 The neuronal cell adhesion molecule (NCAM) is a key mediator of structural plasticity in the central nervous system, but the mechanisms that control its expression are unknown. Equally, although the transcription factor NF-kappaB is present in the brain, few NF-kappaB-regulated genes relevant for central nervous system function have been identified. We
C S, Simpson, B J, Morris
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Neuronal cell adhesion molecule regulating neural systems underlying addiction
Neuropsychopharmacology Reports, 2018 AbstractAimsThe human NRCAM gene is associated with polysubstance use. Nrcam knockout mice do not acquire a preference for addictive substances. We aimed to elucidate the role of Nrcam in specific neural circuits underlying congenital preference for substances and the acquisition of addiction.MethodsWe analyzed gene expression patterns of neural ...
Hiroki Ishiguro +5 more
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Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM +8 more
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APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]
, 1993 Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Beyreuther, K. +5 more
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Multiple cell adhesion molecules shaping a complex nicotinic synapse on neurons [PDF]
Molecular and Cellular Neuroscience, 2008 Neuroligin, SynCAM, and L1-CAM are cell adhesion molecules with synaptogenic roles in glutamatergic pathways. We show here that SynCAM is expressed in the chick ciliary ganglion, embedded in a nicotinic pathway, and, as shown previously for neuroligin and L1-CAM, acts transcellularly to promote synaptic maturation on the neurons in culture.
Gallen B, Triana-Baltzer +3 more
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