Results 291 to 300 of about 271,506 (342)

Cell adhesion molecule L1 promotes neurite outgrowth of septal neurons

Journal of Neuroscience Research, 2004
AbstractTo establish if the cell adhesion molecule L1 could promote neurite outgrowth of septal neurons, L1‐positive substrates were prepared by genetically modifying 3T3 fibroblasts with a retroviral vector encoding human L1 under the control of a negative tetracycline‐regulatory system.
Isabelle, Frappé, Christine, Wang, Geoffrey, Caines, Shawna, Rideout-Gros, Isabelle, Aubert   +4 more
openaire   +2 more sources

Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia

Brain Research, 1999
Telencephalin (TLCN) is a neuronal surface glycoprotein whose expression is restricted to the telencephalon, the most rostral segment of the brain. TLCN binds to lymphocyte function-associated antigen-1 (LFA-1) integrin. In the central nervous system, LFA-1 is selectively and constitutively expressed by microglia, suggesting that TLCN/LFA-1 binding may
T, Mizuno, Y, Yoshihara, H, Kagamiyama, K, Ohsawa, Y, Imai, S, Kohsaka, K, Mori   +6 more
openaire   +2 more sources

Function of a Cell Adhesion Molecule, Plexin, in Neuron Network Formation

Developmental Neuroscience, 1997
Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the c-met proto-oncogene protein product.
H, Fujisawa, K, Ohta, T, Kameyama, Y, Murakami   +3 more
openaire   +2 more sources

Neuronal cell–cell adhesion depends on interactions of N-CAM with heparin-like molecules

Nature, 1986
Cell-cell interactions are of critical importance during neural development, particularly since the migration of neural cells and the establishment of functional interactions between growing axons and their target cells has been suggested to depend upon cell recognition processes. Neurone-neurone adhesion has been well studied in vitro, and is mediated
G. J. Cole, A. Loewy, L. Glaser
semanticscholar   +3 more sources

Neuronal Cell Adhesion Molecule 1 Regulates Leptin Sensitivity and Bone Mass

Calcified Tissue International, 2017
The central nervous system is widely known to exert control over our systemic physiology via several mechanisms including the regulation of skeletal metabolism. Neuronal circuits within the hypothalamus have been shown to impact bone mass via leptin-dependent and independent mechanisms; however, the full extent to which the brain controls bone ...
Xin Yan, Natalia L. Kononenko, Annemarie Brüel, Jesper Skovhus Thomsen, Matthew N. Poy   +4 more
openaire   +2 more sources

Bidirectional Signaling Between Neurons and Glial Cells Via the F3 Neuronal Adhesion Molecule

1999
F3, a glycosyl-phosphatidylinositol anchored molecule of the immunoglobulin superfamily, is known to influence axonal growth and fasciculation via multiple interactions of its modular immunoglobulin-like domains. We prepared a Fc chimeric molecule (F3IgFc) to identify a) the phenotype of cells bearing F3Ig receptors, b) the glial-expressed molecules ...
Revest, Jean-Michel, Faivre-Sarrailh, C., Schachner, M., Rougon, G.   +3 more
openaire   +3 more sources

Cell Adhesion Molecules and the Migration of LHRH Neurons during Development

Developmental Biology, 1993
During embryogenesis, LHRH neurons arise in the olfactory epithelium, migrate along the olfactory nerve, and enter the forebrain. We have examined the distribution of several cell adhesion molecules (CAMs) in the developing chick olfactory system and brain to determine whether differential distributions of these adhesion molecules might be important in
R B, Norgren, R, Brackenbury
openaire   +2 more sources

Effects of neuronal cell adhesion molecule L1 and nanoparticle surface modification on microglia

Acta Biomaterialia, 2022
Microelectrode arrays for neural recording suffer from low yield and stability partly due to the inflammatory host responses. A neuronal cell adhesion molecule L1 coating has been shown to promote electrode-neuron integration, reduce microglia activation and improve recording.
Neetu Kushwah, Kevin Woeppel, Vaishnavi Dhawan, Delin Shi, Xinyan Tracy Cui   +4 more
openaire   +2 more sources

Neuronal ‘differentiation’ of murine neuroblastoma cells induced by neocarzinostatin: neural cell adhesion molecules

Brain Research, 1993
Neural crest tumor cells which have been pharmacologically induced in culture to undergo neuronal 'differentiation' have been proposed as a model for normal neural crest cell differentiation. We have previously reported that murine neuroblastoma cells treated with the antineoplastic agent neocarzinostatin (NCS) adopt the light microscopic appearance of
J A, Lowengrub, N F, Schor
openaire   +2 more sources

The clinical spectrum of mutations in L1, a neuronal cell adhesion molecule

American Journal of Medical Genetics, 1996
Mutations in the gene encoding the neuronal cell adhesion molecule L1 are responsible for several syndromes with clinical overlap, including X-linked hydrocephalus (XLH, HSAS), MASA (mental retardation, aphasias, shuffling gait, adducted thumbs) syndrome, complicated X-linked spastic paraplegia (SP 1), X-linked mental retardation-clasped thumb (MR-CT ...
Fransen, Erik, Vits, L., Van Camp, Guy, Willems, P.J.   +3 more
openaire   +3 more sources