Results 71 to 80 of about 271,506 (342)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Circadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu

Neurobiology of Sleep and Circadian Rhythms, 2018
The mammalian circadian and sleep-wake systems are closely aligned through their coordinated regulation of daily activity patterns. Although they differ in their anatomical organization and physiological processes, they utilize overlapping regulatory ...
Joanna M. Cooper, Kathryn A. Halter, Rebecca A. Prosser   +2 more
doaj   +1 more source

Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowth. [PDF]

, 1987
Neuronal responses to extracellular matrix (ECM) constituents are likely to play an important role in nervous system development and regeneration. We have studied the interactions of a neuron-like rat pheochromocytoma cell line, PC12, with ECM protein ...
Damsky, CH, Reichardt, LF, Tomaselli, KJ
core  

TiO2 surfaces support neuron growth during electric field stimulation [PDF]

, 2017
The authors are grateful to Francisco Almendros and Ismael Santamaría for help in preparation of the TiO2 substrates. We acknowledge the European Project NERBIOS (NEST/STREP (FP6), 028473-2) for financial support. Maria Canillas acknowledges the JAE-CSIC
Canillas, M, Chinnaro, E, Moreno, B, Rajnicek, A M   +3 more
core   +1 more source

MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density

Scientific Reports, 2016
At neuronal synapses, multiprotein complexes of trans-synaptic adhesion molecules, scaffold proteins and neurotransmitter receptors assemble to essential building blocks required for synapse formation and maintenance.
N. Rademacher, Bettina Schmerl, Jennifer A. Lardong, M. Wahl, S. Shoichet   +4 more
semanticscholar   +1 more source

Ng-CAM, A Neuron-Glia and Neuron-Neuron Cell Adhesion Molecule.

Trends in Glycoscience and Glycotechnology, 1992
ニューロン-グリア細胞接着分子 (Ng-CAM) は、ニューロン-リア間及びニューロン-ニューロン聞の接着に関与する。Ng-CAMは、ニューロンにおいて6kbの大きさのmRNAから、先ず約200kDaの大きさの蛋白質として合成され、切断されて135kDa及び80kDaのふたつの構成蛋白質となる。そのアミノ酸配列から、6個のイムノグロブリン・ドメイン、5個のフィブロネクチンIII型繰り返し構造、膜貫通ドメイン、そして細胞内ドメインから構成されていることがわかった。Ng-CAMによる接着は、ニユーロンーニューロン間の接着については同種分子間機構によって、またニューロン・アストロサイト間の接着については異種分子間機構によって行われている。Ng-CAMは、ニューロンやシュワン細胞には発現されているが ...
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

On the Teneurin Track: A New Synaptic Organization Molecule Emerges

Frontiers in Cellular Neuroscience, 2015
To achieve proper synaptic development and function, coordinated signals must pass between the pre- and postsynaptic membranes. Such transsynaptic signals can be comprised of receptors and secreted ligands, membrane associated receptors, and also pairs ...
Timothy James Mosca
doaj   +1 more source

Measuring cell adhesion forces with the atomic force microscope at the molecular level [PDF]

, 2002
In the past 25 years many techniques have been developed to characterize cell adhesion and to quantify adhesion forces. Atomic force microscopy (AFM) has been used to measure forces in the pico-newton range, an experimental technique known as force ...
Benoit, M., Gaub, H. E.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source