Results 91 to 100 of about 1,625,351 (310)
Elements of divergence in germline determination in closely related species
iScience, 2023 Summary: Evolutionary transitions are particularly important in development of the germ line, cells which directly impact sexual reproduction. Differences in the primordial germ cells (PGCs) of two sea urchin species were examined here by stage-matched ...
Shumpei Morita +3 more
doaj
Guidelines for reporting cell types: the MIRACL standard [PDF]
arXiv, 2022 Cell types are at the root of modern biology, and describing them is a core task of the Human Cell Atlas project. Surprisingly, there are no standards for reporting new cell types, leading to a gap between classes mentioned in biomedical literature and the Cell Ontology, the primary registry of cell types.
arxiv
Human enzyme-mediated, systemic depletion of methionine for glioblastoma treatment [PDF]
Glioblastoma multiforme (GBM) is the most lethal and common type of malignant brain tumor in adults. To date, no curative treatment exists for GBM despite continuous research efforts.
Chen, Zhao, Ph. D. in cell and molecular biology
core +2 more sources
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
iScience, 2023 Summary: Low circulating phosphate (Pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (HCs) in the growth plate due to impaired HC apoptosis.
Prem Swaroop Yadav +3 more
doaj
A low-cost, user-friendly rheo-optical compression assay to measure mechanical properties of cell spheroids in standard cell culture plates [PDF]
arXiv, 2023 The mechanical characterization of cell spheroids, one of the most widely used 3D biology models in vitro, is a hotspot of current research on the role played by the mechanical response of cells and tissues. The techniques proposed so far in the literature, while providing important scientific insights, require a specialized equipment and technical ...
arxiv
FEBS Letters, EarlyView.In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri +8 more
wiley +1 more source
Cell biology of CML cells [PDF]
Leukemia, 1999 At the cellular level, expansion of haemopoiesis in chronic myeloid leukaemia (CML) must involve some imbalance in cell production along the myeloid maturation pathway. The relevant kinetic parameters are cell loss by apoptosis and differentiation and cell gain by proliferation (self-renewal).
Gordon, M. Y. +7 more
openaire +3 more sources
Premise and peril of Wnt signaling activation through GSK-3β inhibition
iScience, 2022 Summary: Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders.
Samuel M. Law, Jie J. Zheng
doaj
JCI Insight, 2023 The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown.
Benedict Abdon +10 more
doaj +1 more source