Results 91 to 100 of about 3,638,096 (304)

A physical model of cell metabolism [PDF]

, 2018
Cell metabolism is characterized by three fundamental energy demands: to sustain cell maintenance, to trigger aerobic fermentation and to achieve maximum metabolic rate.
Fernandez-de-Cossio-Diaz, Jorge, Vazquez Vazquez, Alexei   +1 more
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in Xenopus oocytes

Scientific Reports
Proteins containing both intrinsically disordered regions (IDRs) and RNA binding domains (RBDs) can phase separate in vitro, forming bodies similar to cellular biomolecular condensates.
Liam C. O’Connell, Victoria Johnson, Jessica P. Otis, Anika K. Hutton, Anastasia C. Murthy, Mark C. Liang, Szu-Huan Wang, Nicolas L. Fawzi, Kimberly L. Mowry   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Hepatocyte-Targeted Epicatechin Nanoparticles Promote Autophagy and Enhance Mitochondrial Function in Metabolic Dysfunction-Associated Steatotic Liver Disease

International Journal of Nanomedicine
Daewon Han,1,2,* Hyeji Lee,1,* Solji Lee,1 Kyubae Lee,3 Nam-Kyung Lee,4,5 Tae-Eun Jin,6 Junguee Lee,7 Jong-Seok Kim,1,2 Do Kyung Kim,8 Jongdae Shin,1,2 Hwan-Woo Park1,2 1Department of Cell Biology, Konyang University College of Medicine ...
Han D, Lee H, Lee S, Lee K, Lee NK, Jin TE, Lee J, Kim JS, Kim DK, Shin J, Park HW   +10 more
doaj  

DNA meets the SVD [PDF]

, 2008
This paper introduces an important area of computational cell biology where complex, publicly available genomic data is being examined by linear algebra methods, with the aim of revealing biological and medical ...
Grindrod, Peter, Higham, Desmond J., Kalna, Gabriela, Spence, Alistair, Stoyanov, Zhivko, Vass, J. Keith   +5 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The membrane curvature-inducing REEP1-4 proteins generate an ER-derived vesicular compartment

Nature Communications
The endoplasmic reticulum (ER) is shaped by abundant membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of four proteins in mammals (REEP1-4), is less abundant and lack a N-terminal region ...
Yoko Shibata, Emily E. Mazur, Buyan Pan, Joao A. Paulo, Steven P. Gygi, Suyog Chavan, L. Sebastian Alexis Valerio, Jiuchun Zhang, Tom A. Rapoport   +8 more
doaj   +1 more source