Results 171 to 180 of about 100,202 (217)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
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The cell biology of cell-in-cell structures
Nature Reviews Molecular Cell Biology, 2008For decades, authors have described unusual cell structures, referred to as cell-in-cell structures, in which whole cells are found in the cytoplasm of other cells. One well-characterized process that results in the transient appearance of such structures is the engulfment of apoptotic cells by phagocytosis.
Joan Brugge +2 more
exaly +3 more sources
2005
Dendritic cells (DCs) are a special type of leukocytes able to alert the immune system to the presence of infections. They play a central role in the initiation of both innate and adaptive immune responses. This particular DC feature is regulated by the activation of specific receptors at the cell surface called Toll-like receptors (TLRs) that bind a ...
GRANUCCI, FRANCESCA +2 more
openaire +2 more sources
Dendritic cells (DCs) are a special type of leukocytes able to alert the immune system to the presence of infections. They play a central role in the initiation of both innate and adaptive immune responses. This particular DC feature is regulated by the activation of specific receptors at the cell surface called Toll-like receptors (TLRs) that bind a ...
GRANUCCI, FRANCESCA +2 more
openaire +2 more sources
Cell
50 years ago, cell biology was a nascent field. Today, it is a vast discipline whose principles and tools are also applied to other disciplines; vice versa, cell biologists are inspired by other fields. So, the question begs: what is cell biology? The answers are as diverse as the people who define it.
Theriot, Julie +12 more
openaire +4 more sources
50 years ago, cell biology was a nascent field. Today, it is a vast discipline whose principles and tools are also applied to other disciplines; vice versa, cell biologists are inspired by other fields. So, the question begs: what is cell biology? The answers are as diverse as the people who define it.
Theriot, Julie +12 more
openaire +4 more sources
Cell biology of the satellite cell
1993Over the past several years the satellite cell in skeletal muscle has been the subject of renewed interest because of its potential importance in therapy for human muscle diseases due to genetic defects such as Duchenne muscular dystrophy (Griggs and Karpati, 1990; Partridge, 1991).
E, Schultz, K M, McCormick
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Cell biology of endothelial cells
Human Pathology, 1987Endothelial cells are a source of physiologically important molecules synthesized therein and secreted to the blood and/or to the subendothelial extracellular matrix. These molecules participate in formation of platelet and fibrin thrombi (e.g., von Willebrand factor and tissue factor) and contribute to antithrombotic properties of the endothelium (e.g.
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American Journal of Respiratory and Critical Care Medicine, 1998
The purpose of this review is to relate developments in lung cell biology to our understanding and treatment of pulmonary diseases. The authors’ careers in pulmonary biology began when we came to the Heart Institute of the National Institutes of Health in 1968 (R.J.M.) and 1970 (R.G.C.).
R J, Mason, R G, Crystal
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The purpose of this review is to relate developments in lung cell biology to our understanding and treatment of pulmonary diseases. The authors’ careers in pulmonary biology began when we came to the Heart Institute of the National Institutes of Health in 1968 (R.J.M.) and 1970 (R.G.C.).
R J, Mason, R G, Crystal
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