Results 181 to 190 of about 3,610,600 (306)
Viral proteins as discovery tools for cell biology: The case of the geminivirus-encoded C4. [PDF]
PLoS PathogPan S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Topological data analysis in single cell biology. [PDF]
Front ImmunolHernández-Lemus E.
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Intravital Microscopy of Osteocytes: A New Era in Bone Cell Biology. [PDF]
Curr Osteoporos RepWasi M, Lewis KJ.
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Adaptation of lentiviral vectors for viral gene therapy and their impact on host cell biology. [PDF]
J Transl MedKaiser CW, Rouchka EC, Smith ML.
europepmc +1 more source