Results 21 to 30 of about 3,584,225 (304)
Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14
Stem Cell Research & Therapy, 2019 Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation.
Egle-Helene Ervin +6 more
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Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]
, 2009 Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley +108 more
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A homozygous genome‐edited Sept2‐EGFP fibroblast cell line [PDF]
, 2019 Septins are a conserved, essential family of GTPases that interact with actin, microtubules, and membranes and form scaffolds and diffusion barriers in cells. Several of the 13 known mammalian septins assemble into nonpolar, multimeric complexes that can
Banko, Monika +4 more
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Global parameter identification of stochastic reaction networks from single trajectories [PDF]
, 2011 We consider the problem of inferring the unknown parameters of a stochastic biochemical network model from a single measured time-course of the concentration of some of the involved species.
A Auger +38 more
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iScience, 2023 Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang +11 more
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Oncogenic microRNAs characterization in clear cell renal cell carcinoma [PDF]
, 2015 A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of
BELLISSIMO, TERESA +8 more
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Trakya University Journal of Natural Sciences, 2019 Cancer is becoming the leading cause of death all around the world. To develop better therapeutic options against cancer, we need a thorough understanding of tumor development and dissemination. As our knowledge increases, it becomes apparent that cancer
Serkan İsmail Göktuna +2 more
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mRNA splicing is modulated by intronic microRNAs
iScience, 2023 Summary: Splicing of transcripts is catalyzed by the spliceosome, a mega-complex consisting of hundreds of proteins and five snRNAs, which employs direct interactions. When U1 snRNA forms high-affinity binding, namely more than eight base pairs, with the
Luba Farberov +7 more
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Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging
Molecular & Cellular Oncology, 2018 Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar +5 more
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Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 2010 Cells in the musculoskeletal system are subjected to various mechanical forces in vivo. Years of research have shown that these mechanical forces, including tension and compression, greatly influence various cellular functions such as gene expression ...
Wang James HC, Li Bin
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