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Current Biology, 2006 As with the experimental sciences, the cell simulation field is largely driven by the development of new techniques, and of new tools that implement those techniques. Many techniques under development are working to increase simulation accuracy while reducing the computational burden.
Andrews, Steven S., Arkin, Adam P.
openaire +2 more sources
A Phytochrome-Derived Photoswitch for Intracellular Transport [PDF]
, 2017 Cells depend on the proper positioning of their organelles, suggesting that active manipulation of organelle positions can be used to explore spatial cell biology and to restore cellular defects caused by organelle misplacement.
Willems, Jelmer +6 more
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ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
iScience, 2021 Summary: DNA double-strand break (DSB) repair by homologous recombination (HR) is essential for ensuring genome stability. Abnormal spindle-like microcephaly-associated (ASPM) gene encodes a spindle protein that is commonly implicated in primary ...
Shibin Xu +5 more
doaj +1 more source
iScience, 2021 Summary: Understanding the mechanisms of human pluripotent stem cells (hPSCs) specification, development and differentiation to gametes are useful for elucidating the causes of infertility and potential treatment. This study aims to examine whether hPSCs
Danny C.W. Yu +5 more
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Strengthening Microtubules by Cuts that Heal [PDF]
, 2018 Microtubule-severing enzymes, which can remove tubulin dimers from microtubule lattices, participate in cytoskeletal remodeling in various contexts. A recent study showed that partially damaged microtubule shafts and new microtubule ends generated by ...
Sub Cell Biology +2 more
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GDF5 induces TBX3 in a concentration dependent manner - on a gold nanoparticle gradient
Heliyon, 2020 Organs and tissues, such as cartilage and limbs, are formed during development through an orchestration of growth factors that function as morphogens.
L. Andreasson +2 more
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iScience, 2023 Summary: The DNA-damage response is a complex signaling network that guards genomic integrity. The microtubule cytoskeleton is involved in the repair of DNA double-strand breaks; however, little is known about which cytoskeleton-related proteins are ...
Arlinda Dullovi +6 more
doaj +1 more source
Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14
Stem Cell Research & Therapy, 2019 Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation.
Egle-Helene Ervin +6 more
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Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding
iScience, 2022 Summary: A delicate balance of BMP activity is critical for tissue formation and organogenesis. However, the mechanical molecular details in ensuring the proper duration and intensity of BMP signaling have yet to be fully elucidated.
Shuyan Yang +7 more
doaj +1 more source
Prostate epithelium basement membrane and prostate cell biology: 20 years [PDF]
, 2017 Department of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP)IBILCE Universidade Estadual Júlio de Mesquita Filho (UNESP)Department of Morphology Institute of Biosciences Universidade Estadual Júlio de ...
Manoel F. Biancardi +7 more
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