Results 41 to 50 of about 3,447,785 (360)

Interactive learning in biology with PhotoCD and associated software [PDF]

, 1995
This paper describes the pioneering development of flexible‐learning courseware in the teaching and learning of cell biology using a novel optical disk‐based technology — PhotoCD — and its associated computer software.
Baggott, Linda, Wright, Bruce
core   +2 more sources

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

Human pluripotent stem cell-derived DDX4 and KRT-8 positive cells participate in ovarian follicle-like structure formation

iScience, 2021
Summary: Understanding the mechanisms of human pluripotent stem cells (hPSCs) specification, development and differentiation to gametes are useful for elucidating the causes of infertility and potential treatment. This study aims to examine whether hPSCs
Danny C.W. Yu, Fang-Chun Wu, Chia-Eng Wu, Lu-Ping Chow, Hong-Nerng Ho, Hsin-Fu Chen   +5 more
doaj  

The Cell Physiome: What do we need in a computational physiology framework for predicting single cell biology? [PDF]

arXiv, 2022
Modern biology and biomedicine are undergoing a big-data explosion needing advanced computational algorithms to extract mechanistic insights on the physiological state of living cells. We present the motivation for the Cell Physiome: a framework and approach for creating, sharing, and using biophysics-based computational models of single cell ...
arxiv  

Linking specification to differentiation:From proneural genes to the regulation of ciliogenesis [PDF]

, 2011
Much of developmental biology is concerned with the processes by which cells become committed to particular fates in a regulated fashion, whereas cell biology addresses, among other things, the variety of differentiated forms and functions that cells can
Jarman, Andrew, Simpson, T Ian, Zur Lage, Petra I   +2 more
core   +2 more sources

ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

iScience, 2021
Summary: DNA double-strand break (DSB) repair by homologous recombination (HR) is essential for ensuring genome stability. Abnormal spindle-like microcephaly-associated (ASPM) gene encodes a spindle protein that is commonly implicated in primary ...
Shibin Xu, Xingxuan Wu, Peipei Wang, Sheng-Li Cao, Bin Peng, Xingzhi Xu   +5 more
doaj  

CELL BIOLOGY AND SIGNALING [PDF]

Neuro-Oncology, 2010
The phylogenetically-conserved vertebrate transcription factor, NFIB, is an orchestrator of glial differentiation in the developing mammalian central nervous system. We found NFIB expression to be reduced in glioblastoma (GBM), the commonest and most lethal primary adult brain cancer, so investigated what effect increased expression of NFIB had on GBM.
M. Agarwal, R. Nitta, S. Dovat, G. Li, H. Arita, Y. Narita, S. Fukushima, K. Tateishi, Y. Matsushita, A. Yoshida, Y. Miyakita, M. Ohno, V. P. Collins, N. Kawahara, S. Shibui, K. Ichimura, S. A. Kahn, S. Gholamin, M.-P. Junier, H. Chneiweiss, I. Weissman, S. Mitra, S. Cheshier, T. Avril, A. Hamlat, P.-J. Le Reste, J. Mosser, V. Quillien, C. Carrato, A. Munoz-Marmol, L. Serrano, L. Pijuan, C. Hostalot, S. l. Villa, A. Ariza, O. Etxaniz, C. Balana, E. T. Benveniste, Y. Zheng, B. McFarland, D. Drygin, S. Bellis, M. Bredel, D. Lotsch, C. Engelmaier, S. Allerstorfer, M. Grusch, J. Pichler, S. Weis, J. Hainfellner, C. Marosi, S. Spiegl-Kreinecker, W. Berger, A. Bronisz, M. O. Nowicki, Y. Wang, K. Ansari, E. A. Chiocca, J. Godlewski, K. Brown, M. Kwatra, K. Brown, M. Kwatra, T. Bui, R. Nitta, G. Li, S. Zhu, D. Kozono, J. Li, D. Kushwaha, B. Carter, C. Chen, J. Schulte, M. Srikanth, S. Das, J. Zhang, J. Lathia, L. Yin, J. Rich, E. Olson, J. Kessler, A. Chenn, A. Cherry, B. Haas, Y. H. Lin, S.-E. Ong, N. Stella, C. P. Cifarelli, R. J. Griffin, D. Cong, W. Zhu, Y. Shi, P. Clark, J. Kuo, S. Hu, D. Sun, M. Bookland, N. Darbinian, A. Dey, M. Robitaille, M. Remke, D. Faury, C. Maier, A. Malhotra, N. Jabado, M. Taylor, S. Angers, A. Kenney, X. Ren, H. Zhou, M. Schur, A. Baweja, M. Singh, A. Erdreich-Epstein, J. Fu, D. Koul, J. Yao, N. Saito, S. Zheng, R. Verhaak, Z. Lu, W. K. A. Yung, G. Gomez, S. Volinia, C. Croce, C. Brennan, W. Cavenee, F. Furnari, S. G. Lopez, D. Qu, C. Petritsch, M. Gonzalez-Huarriz, G. Aldave, D. Ravi, A. Rubio, R. Diez-Valle, M. Marigil, P. Jauregi, B. Vera, A. A. d. l. Rocha, S. Tejada-Solis, M. M. Alonso, U. Gopal, J. Isaacs, M. Gruber-Olipitz, S. Dabral, S. Ramkissoon, A. Kung, E. Pak, J. Chung, M. Theisen, Y. Sun, V. Monrose, Y. Franchetti, Y. Sun, D. Shulman, N. Redjal, B. Tabak, R. Beroukhim, J. Zhao, S. Buonamici, K. Ligon, J. Kelleher, R. Segal, B. Haas, D. Canton, P. Diaz, J. Scott, N. Stella, K. Hara, T. Kageji, Y. Mizobuchi, K. Kitazato, T. Okazaki, T. Fujihara, K. Nakajima, H. Mure, K. Kuwayama, T. Hara, S. Nagahiro, L. Hill, H. Botfield, K. Hossain-Ibrahim, A. Logan, G. Cruickshank, Y. Liu, M. Gilbert, N. Kyprianou, V. Rangnekar, C. Horbinski, Y. Hu, C. Vo, Z. Li, C. Ke, N. Ru, K. R. Hess, M. E. Linskey, Y.-a. H. Zhou, F. Hu, K. Vinnakota, S. P. Niclou   +200 more
openaire   +4 more sources

Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

iScience, 2023
Summary: The DNA-damage response is a complex signaling network that guards genomic integrity. The microtubule cytoskeleton is involved in the repair of DNA double-strand breaks; however, little is known about which cytoskeleton-related proteins are ...
Arlinda Dullovi, Meryem Ozgencil, Vinothini Rajvee, Wai Yiu Tse, Pedro R. Cutillas, Sarah A. Martin, Zuzana Hořejší   +6 more
doaj  

Mechanobiology of Collective Cell Migration in 3D Microenvironments [PDF]

arXiv, 2022
Tumor cells invade individually or in groups, mediated by mechanical interactions between cells and their surrounding matrix. These multicellular dynamics are reminiscent of leader-follower coordination and epithelial-mesenchymal transitions (EMT) in tissue development, which may occur via dysregulation of associated molecular or physical mechanisms ...
arxiv  

The cell biology of touch [PDF]

Journal of Cell Biology, 2010
The sense of touch detects forces that bombard the body’s surface. In metazoans, an assortment of morphologically and functionally distinct mechanosensory cell types are tuned to selectively respond to diverse mechanical stimuli, such as vibration, stretch, and pressure.
Aislyn M. Nelson, Ellen A. Lumpkin, Kara L. Marshall   +2 more
openaire   +3 more sources