Results 41 to 50 of about 599,411 (264)
Exosomal miRNAs as cancer biomarkers and therapeutic targets [PDF]
Journal of Extracellular Vesicles, 2016 Intercommunication between cancer cells and with their surrounding and distant environments is key to the survival, progression and metastasis of the tumour. Exosomes play a role in this communication process.
Arron Thind, Clive Wilson
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
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Cell–cell communication in kidney fibrosis
Nephrology Dialysis Transplantation, 2023 ABSTRACT Kidney fibrosis is a common outcome of a wide variety of chronic kidney diseases, in which virtually all kinds of renal resident and infiltrating cells are involved. As such, well-orchestrated intercellular communication is of vital importance in coordinating complex actions during renal fibrogenesis.
Meizhi He, Zhao Liu, Li Li, Youhua Liu
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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Screening of MicroRNAs with Potential Systemic Effects Released from Goose Fatty Liver
The Journal of Poultry Science, 2021 Communication between tissues and organs plays an important role in the maintenance of normal physiological functions as well as the occurrence and development of diseases.
Xue Fan +10 more
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
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Clinical, Cosmetic and Investigational Dermatology, 2023 Chen-Xi Zhao, Shi-Lei Wang, Hai-Xia Li, Xin Li Department of Cosmetology and Dermatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, People’s Republic of ChinaCorrespondence: Xin Li, Department of Cosmetology and Dermatology ...
Zhao CX, Wang SL, Li HX, Li X
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Frontiers in ImmunologyBackgroundThe role of cancer-associated pericytes (CAPs) in tumor microenvironment (TME) suggests that they are potential targets for cancer treatment. The mechanism of CAP heterogeneity in esophageal squamous cell carcinoma (ESCC) remains unclear, which
Kai Xiong, Bing Pan, Hao Fang, Ziyou Tao
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