Advanced Cell Culture Techniques for Cancer Drug Discovery [PDF]
Biology, 2014 Human cancer cell lines are an integral part of drug discovery practices. However, modeling the complexity of cancer utilizing these cell lines on standard plastic substrata, does not accurately represent the tumor microenvironment.
Carrie J. Lovitt +2 more
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“Humanized” Stem Cell Culture Techniques: The Animal Serum Controversy [PDF]
Stem Cells International, 2011 Cellular therapy is reaching a pinnacle with an understanding of the potential of human mesenchymal stem cells (hMSCs) to regenerate damaged tissue in the body. The limited numbers of these hMSCs in currently identified sources, like bone marrow, adipose
Chandana Tekkatte +3 more
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Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Frontiers in Molecular Biosciences, 2020 Cell culture is an important and necessary process in drug discovery, cancer research, as well as stem cell study. Most cells are currently cultured using two-dimensional (2D) methods but new and improved methods that implement three-dimensional (3D ...
Caleb Jensen +5 more
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Study on human chondrocyte culture viability for autologous transplantation in clinical application [PDF]
Einstein (São Paulo), 2003 Objective: The limited regenerative capacity of the cartilage tissuemakes the treatment of chondral lesions difficult. The techniquescurrently available to treat cartilage lesions may relieve symptoms,but do not regenerate the injured tissue.
Christiane Lombello +2 more
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Applied Sciences, 2023 The laser treatment and hydroxyapatite coating of dental implants are supposed to enhance osseointegration, but prior to preclinical testing, any negative impact on cell viability should be ruled out.
Ana Flávia Piquera Santos +7 more
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Development and validation of a vero cell-based suspension method for the detection of Zika virus
Revista Peruana de Medicina Experimental y Salud Pública, 2023 Objective. To develop and validate a cell suspension method using Vero 76 cells for culturing Zika virus (ZIKV) based on infection of detached freshly seeded cells. Material and methods.
Dina Popuche +5 more
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Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids [PDF]
Organoid, 2021 Animal models have been standard methods for non-clinical research in drug development for decades. However, many drugs that have shown satisfactory results in non-clinical studies have failed in the clinical stage, presumably because animal data are not
Hanbyeol Lee +3 more
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Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa [PDF]
European Cells & Materials, 2018 The combination of gene therapy and tissue engineering is one of the most promising strategies for the treatment of recessive dystrophic epidermolysis bullosa (RDEB).
A Dakiw Piaceski +8 more
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Explant Culture of Ovarian Tissue
Van Tıp Dergisi, 2022 INTRODUCTION: In this study, it was aimed to isolate, reproduce and characterize stromal cells migrating from tissues by creating ovarian tissue explant culture.
Murat Serkant Ünal +6 more
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Impact of experiential learning among medical undergraduates: A randomized controlled trial
Journal of Education and Health Promotion, 2020 BACKGROUND: Experiential learning sessions as a teaching aid have been applied early in the medical undergraduate curriculum to improve the knowledge and inculcate research interest.
Akila Prashant +3 more
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