Results 11 to 20 of about 1,114,098 (265)

Advanced Cell Culture Techniques for Cancer Drug Discovery [PDF]

Biology, 2014
Human cancer cell lines are an integral part of drug discovery practices. However, modeling the complexity of cancer utilizing these cell lines on standard plastic substrata, does not accurately represent the tumor microenvironment. Research into developing advanced tumor cell culture models in a three-dimensional (3D) architecture that more prescisely
Carrie Lovitt, Todd Shelper, Vicky Avery
openaire   +6 more sources

The contribution of age structure to cell population responses to targeted therapeutics [PDF]

, 2012
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner.
Ackleh, Ackleh, Ainseba, Ainseba, Alarcón, Angulo, Angulo, Arino, Banks, Bekkal Brikci, Bekkal Brikci, Bernard, Calsina, Darren R. Tyson, Diekmann, Douglas, Doumic, Doumic, Dowling, Engel, Engl, Gabriel, Gabriel, Gerlee, Glenn F. Webb, Golubev, Gyllenberg, Gyllenberg, Gyllenberg, Hinow, Kostova, Lee, Liu, Mallet, Michel, Patel, Perthame, Perthame, Picart, Picart, Pierre Gabriel, Pilant, Pilant, Powathil, Quaranta, Quaranta, Ramis-Conde, Ribba, Rundell, Rundell, Shawn P. Garbett, Vito Quaranta, Webb   +52 more
core   +7 more sources

Nuclear DNA and protein content evaluation in Taxus plant cell cultures using multiparameter flow cytometry [PDF]

, 2009
Plant cell cultures of Taxus provide the most reliable production methods for the anti-cancer drug paclitaxel. In order to comprehend the inherent culture heterogeneity and production variability in cell cultures, it is essential that the cellular ...
Amit Shavit, Susan C. Roberts, Vishal Gaurav   +2 more
core   +2 more sources

Environmental monitoring of Mycobacterium bovis in badger feces and badger sett soil by real-time PCR, as confirmed by immunofluorescence, immunocapture, and cultivation [PDF]

, 1999
Real-time PCR was used to detect and quantify Mycobacterium bovis cells in naturally infected soil and badger faeces. Immunomagnetic capture, immunofluorescence and selective culture confirmed species identification and cell viability.
Sweeney, F. P., Courtenay, Orin, Hibberd, V., Hewinson, R. G., Reilly, L. A., Gaze, William H., Wellington, E. M. H.   +6 more
core   +4 more sources

The changing role of cell culture in the generation of transgenic livestock [PDF]

, 1999
Transgenesis may allow the generation of farm animals with altered phenotype, animal models for research and animal bioreactors. Although such animals have been produced, the time and expense involved in generating transgenic livestock and then ...
Farini, E, Webster, J, Whitelaw, C B
core   +1 more source

An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen [PDF]

, 2015
The ability to rapidly secrete cytokines upon stimulation is a functional characteristic of the invariant natural killer T (iNKT) cell lineage. iNKT cells are therefore characterized as an innate T cell population capable of activating and steering ...
Drennan, Michael, Elewaut, Dirk, Govindarajan, Srinath   +2 more
core   +1 more source

Opportunities for organoids as new models of aging. [PDF]

, 2018
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica, Arora, Astashkina, Auger, Aw, Azpurua, Barbero, Barkauskas, Barkauskas, Barker, Bartfeld, Behjati, Belmin, Ben-Ze’ev, Bhumiratana, Blau, Blokzijl, Brack, Broutier, Busuttil, Caron, Caughey, Cerchiari, Chambers, Chang, Chaudhuri, Choi, Cornacchia, Crabb, Danahay, Dekkers, Dos Santos, Dye, Eiraku, Elahy, Engevik, Freedman, Gao, Garbe, Gjorevski, Greider, Gullapalli, Hannum, Hansen, Hegab, Heintz, Hibiya, Hohwieler, Horvath, Htwe, Huch, Huch, Jennifer L. Hu, Jones, Jung, Karthaus, Kolesky, Koo, Kwong, Lang, Lee, Lee, Levental, Li, Li, Lindahl, Linnemann, Liu, Lozito, Lyons, López-Otín, L’Heureux, Madden, Marciniak, Mark A. LaBarge, Matsui, Mattison, McElwee, Meerwaldt, Mertens, Messner, Michael E. Todhunter, Miller, Moore, Moore, Morizane, Murrow, Myers, Nalapareddy, Nasto, Nelson, Nevalainen, Nguyen-Ngoc, Nicholas, Noguchi, Ootani, O’Brien, Pageon, Pang, Parrinello, Pauli, Phillip, Plaks, Pribluda, Qian, Raja, Rangarajan, Rodriguez-Teja, Ruan, Sancar, Sato, Schütte, Seok, Simian, Singh, Squires, Stampfer, Stearns-Reider, Stojadinovic, Sun, Takasato, Takebe, Tan, Tanos, Toda, Todhunter, Turco, Tzatzalos, van Vliet, Vanhooren, Vernetti, Verzijl, Villadsen, Villeda, Voytik-Harbin, Watson, Williams, Wilson, Workman, Wu, Wylie, Xiang, Yilmaz, Zev J. Gartner, Zhang, Zhang   +145 more
core   +2 more sources

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss [PDF]

, 2005
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration.
Petzold, A
core   +1 more source

Introducing monitoring and automation in cartilage tissue engineering, toward controlled clinical translation [PDF]

, 2011
The clinical application of tissue engineered products requires to be tightly connected with the possibility to control the process, assess graft quality and define suitable release criteria for implantation.
Santoro, Rosaria
core   +1 more source

Water-stable plasma-polymerized N,N-dimethylacrylamide coatings to control cellular adhesion [PDF]

, 2020
The plasma polymerization of amide-based precursors is a nearly unexplored research area, which is in contrast with the abundance of reports focusing on amide based surface modification using wet chemistry.
Asadian, Mahtab, Cools, Pieter, De Geyter, Nathalie, Declercq, Heidi, Egghe, Tim, Hoogenboom, Richard, Khalenkow, Dmitry, Morent, Rino, Nikiforov, Anton, Skirtach, Andre, Van Guyse, Joachim   +10 more
core   +2 more sources