Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies
Biomedicines, 2022 The central nervous system (CNS) injury, which occurs because of mechanical trauma or ischemia/hypoxia, is one of the main causes of mortality and morbidity in the modern society.
Kristina Pilipović +3 more
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A low-cost, user-friendly rheo-optical compression assay to measure mechanical properties of cell spheroids in standard cell culture plates [PDF]
arXiv, 2023 The mechanical characterization of cell spheroids, one of the most widely used 3D biology models in vitro, is a hotspot of current research on the role played by the mechanical response of cells and tissues. The techniques proposed so far in the literature, while providing important scientific insights, require a specialized equipment and technical ...
arxiv
Memantine protects the cultured rat hippocampal neurons treated by NMDA and amyloid β1–42
Frontiers in Neuroscience, 2023 Alzheimer’s disease (AD) is a devastating neurodegenerative condition with no effective treatments. Recent research highlights the role of NMDA receptors in AD development, as excessive activation of these receptors triggers excitotoxicity. Memantine, an
Nataliia M. Rozumna +2 more
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Journal of Applied Oral Science, 2007 The objective of the present study was to characterize bone cells grown in two culture media, and to determine the effective concentration of OP-1 on the growth of osteo-1 cells.
Adriane Yaeko Togashi +4 more
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The changing role of cell culture in the generation of transgenic livestock [PDF]
, 1999 Transgenesis may allow the generation of farm animals with altered phenotype, animal models for research and animal bioreactors. Although such animals have been produced, the time and expense involved in generating transgenic livestock and then ...
Farini, E, Webster, J, Whitelaw, C B
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Design of thiol–ene photoclick hydrogels using facile techniques for cell culture applications
Biomaterials Science, 2014 Thiol–ene photoclick hydrogels with tunable biomechanical and biochemical properties for biological applications, including controlled cell culture, regenerative medicine, and drug delivery.
L. Sawicki, April M. Kloxin
semanticscholar +1 more source
Cytocentric measurement for regenerative medicine
Frontiers in Medical Technology, 2023 Any Regenerative Medicine (RM) business requires reliably predictable cell and tissue products. Regulatory agencies expect control and documentation. However, laboratory tissue production is currently not predictable or well-controlled. Before conditions
Alicia D. Henn +11 more
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Development and cytotoxic response of two proliferative MDA- MB-231 and non-proliferative SUM1315 three-dimensional cell culture models of triple-negative basal-like breast cancer cell lines [PDF]
, 2017 Triple-Negative Basal-Like tumors, representing 15 to 20% of breast cancers, are very aggressive and with poor prognosis. Targeted therapies have been developed extensively in preclinical and clinical studies to open the way for new treatment strategies.
arxiv +1 more source
Opportunities for organoids as new models of aging. [PDF]
, 2018 The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica +145 more
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Razor scrape assay, an alternative variation to wound and healing assays
MethodsX, 2020 Cell migration is the process by which cells move through tissues, and it is crucial to carry out a wide variety of physiological and pathological processes.
Jesús Antonio Lara-Reyes +8 more
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