Results 121 to 130 of about 16,339,920 (405)

Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression

Cell Cycle, 2016
Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells continue division before acquiring a fully differentiated state, while terminal differentiation usually coincides with proliferation arrest and permanent exit ...
S. Ruijtenberg, S. van den Heuvel
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

CDK1-PP2A-B55 interplay ensures cell cycle oscillation via Apc1-loop300

Cell Reports
Summary: Cell cycle control relies on a delicate balance of phosphorylation with CDK1 and phosphatases like PP1 and PP2A-B55. Yet, identifying the primary substrate responsible for cell cycle oscillations remains a challenge.
Kim Hou Chia, Hiroko Takaki, Kazuyuki Fujimitsu, Sarah Darling, Juan Zou, Juri Rappsilber, Hiroyuki Yamano   +6 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

DNA damage signalling histone H2AX is required for tumour growth

Cell Death Discovery
Cancer most frequently develops in self-renewal tissues that are the target of genetic alterations due to mutagens or intrinsic DNA replication errors.
Lizbeth Contreras, Lorena García-Gaipo, Berta Casar, Alberto Gandarillas   +3 more
doaj   +1 more source

An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules

Nature Communications, 2018
Ubiquitination and ubiquitin-like modifications of proteins regulate multiple cellular processes but identifying substrates of specific E2 and E3 enzymes remains challenging. Here, the authors conjugate E2 enzymes with enrichable ubiquitin derivatives to
Gábor Bakos, Lu Yu, Igor A. Gak, Theodoros I. Roumeliotis, Dimitris Liakopoulos, Jyoti S. Choudhary, Jörg Mansfeld   +6 more
doaj   +1 more source

E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family. [PDF]

, 2019
E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4 often represents the predominant E2F activity in cells.
Arand, Julia, Brison, Caileen M, Chaikovsky, Andrea, Demeter, Janos, Hsu, Jenny, Jackson, Peter K, Mooney, Nancie A, Oliverio, Romane, Rubin, Seth M, Sage, Julien, Vogel, Hannes   +10 more
core  

Cell cycle checkpoint signaling through the ATM and ATR kinases.

Genes & Development, 2001
The genomes of eukaryotic cells are under continuous assault by environmental agents (e.g., UV light and reactive chemicals) as well as the byproducts of normal intracellular metabolism (e.g., reactive oxygen intermediates and inaccurately replicated DNA)
R. Abraham
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Targeting cell-cycle machinery in cancer.

Cancer Cell, 2021
Jan M. Suski, Marcin Braun, V. Strmiska, P. Sicinski   +3 more
semanticscholar   +1 more source