Results 61 to 70 of about 8,365,967 (315)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Cell cycle control and its modulation in HPV infected cells [PDF]

, 2010
A key effect of human papillomavirus (HPV) infection is to disrupt the normal cell cycle in order to subvert the cellular DNA replication machinery. Morphologically, condylomata induced by high and low risk HPV types cannot be distinguished and many ...
Lyman, Rachel C.
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

TOR regulates variability of protein synthesis rates

The EMBO Journal
Cellular processes are subject to inherent variability, but the extent to which cells can regulate this variability has received little investigation. Here, we explore the characteristics of the rate of cellular protein synthesis in single cells of the ...
Clovis Basier, Paul Nurse
doaj   +1 more source

Phasing in on the cell cycle [PDF]

Cell Division, 2018
Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate biochemical reactions. Moreover, this discovery has provided a new framework for the study of membrane-less organelle biogenesis and protein ...
Steven Boeynaems, Peter Tompa, Ludo Van Den Bosch   +2 more
openaire   +5 more sources

MEK1/2 regulates microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte meiotic maturation

, 2007
It is well known that MAPK plays pivotal roles in oocyte maturation, but the function of MEK (MAPK kinase) remains unknown. We have studied the expression, subcellular localization and functional roles of MEK during meiotic maturation of mouse oocytes ...
Bo Xiong, Qing-Yuan Sun, Wang, Chun Min, Zhi-Sheng Zhong, Kui Liu, Schatten, Heide, Yi Hou, Wang, Qiang, Chen, Da-Yuan, Yu, Ling-Zhu, Zhong, Zhi-Sheng, Wang, Chun-Min, Sun, Qing-Yuan, Liu, Kui, Zhong, Zhi Sheng, Da-Yuan Chen, Qiang Wang, Gao, Wen Xue, Huo, Li-Jun, Yu, Ling Zhu, Liu, X. Johne, Sun, Qing Yuan, Huo, Li Jun, Chen, Da Yuan, Wen-Xue Gao, Ling-Zhu Yu, Li-Jun Huo, Xiong, Bo, Heide Schatten, Gao, Wen-Xue, Chun-Min Wang, Johné Liu, Hou, Yi   +32 more
core   +1 more source

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan [PDF]

, 2008
A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent ...
Ali, Reza, Khan, Imtiaz Ali, Godfrey, Keith, Evans, Neil D., Khan, I. A., Errington, Rachel J., Campbell, L., Smith, Paul J., Smith, Paul James, Ali, R., Chappell, M. J. (Michael J.), Chappell, Michael J., Godfrey, K. R., Campbell, Lee, Errington, Rachel Jane, Evans, N. D.   +15 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Quantitative Cell Cycle Analysis Based on an Endogenous All-in-One Reporter for Cell Tracking and Classification

Cell Reports, 2017
Cell cycle kinetics are crucial to cell fate decisions. Although live imaging has provided extensive insights into this relationship at the single-cell level, the limited number of fluorescent markers that can be used in a single experiment has hindered ...
Thomas Zerjatke, Igor A. Gak, Dilyana Kirova, Markus Fuhrmann, Katrin Daniel, Magdalena Gonciarz, Doris Müller, Ingmar Glauche, Jörg Mansfeld   +8 more
doaj   +1 more source