Results 61 to 70 of about 8,789,133 (312)

CDK control pathways integrate cell size and ploidy information to control cell division

eLife, 2021
Maintenance of cell size homeostasis is a property that is conserved throughout eukaryotes. Cell size homeostasis is brought about by the co-ordination of cell division with cell growth and requires restriction of smaller cells from undergoing mitosis ...
James Oliver Patterson, Souradeep Basu, Paul Rees, Paul Nurse   +3 more
doaj   +1 more source

Cell Cycle and Apoptosis

Neoplasia, 2000
In multicellular organisms, cell proliferation and death must be regulated to maintain tissue homeostasis. Many observations suggest that this regulation may be achieved, in part, by coupling the process of cell cycle progression and programmed cell death by using and controlling a shared set of factors.
PUCCI, B., KASTEN, M., GIORDANO, A.
openaire   +5 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway

, 2014
Cells with aberrations in chromosomal ploidy are normally removed by apoptosis. However, aneuploid neurons have been shown to remain functional and active both in the cortex and in the retina. Lim1 horizontal progenitor cells in the chicken retina have a
Hallböök, Finn,, All-Ericsson, Charlotta, Fard, Shahrzad Shirazi,, All-Ericsson, C,, Fard, SS, Hallbook, F   +5 more
core   +1 more source

An immunocytochemical approach to the analysis of the cell division cycle in the rat cerebellar neuroepithelium [PDF]

, 2020
Cerebellar neurons are generated from the rhombic lip and the neuroepithelium. In this study, we analyze the histogenesis of the cerebellar neuroepithelium in terms of cellular kinetics.
Martí-Clúa, Joaquín, Rodríguez Vázquez, Lucía, Joaquín Martí, Lucía Rodríguez-Vázquez   +3 more
core   +1 more source

Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage

Cell Reports, 2014
Tumor suppressor p53 is a major cellular guardian of genome integrity, and its inactivation is the most frequent genetic alteration in cancer, rising up to 80% in squamous cell carcinoma (SCC).
Ana Freije, Rut Molinuevo, Laura Ceballos, Marta Cagigas, Pilar Alonso-Lecue, René Rodriguez, Pablo Menendez, Daniel Aberdam, Ernesto De Diego, Alberto Gandarillas   +9 more
doaj   +1 more source

Cell cycle proteins: Linking the cell cycle to tumors

Oncology Research
The cell cycle is a tightly coupled series of events that enable cells to grow and proliferate. Cyclin-dependent kinases (CDKs) play crucial roles in the cell cycle by enabling cells to transition between different phases when they are activated. Cell cycle proteins enhance the activity of CDKs, while natural CDK inhibitors (CDKIs) suppress them.
ZHONG, JIE, LIU, JUE, TANG, XING, ZHOU, WENCHAO, SONG, GUANGMING, ZENG, YUHUAN, ZHANG, XIAODI, ZHOU, JIANBIN, CAO, LU, ZHANG, QUNFENG, LI, YUKUN   +10 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Cell cycle control and its modulation in HPV infected cells [PDF]

, 2010
A key effect of human papillomavirus (HPV) infection is to disrupt the normal cell cycle in order to subvert the cellular DNA replication machinery. Morphologically, condylomata induced by high and low risk HPV types cannot be distinguished and many ...
Lyman, Rachel C.
core   +2 more sources

Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research

Cell Structure and Function
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediated regulation,
Sachiya Nakashima, Aika Toyama, Hironori Sugiyama, Kazuhiro Aoki, Yuhei Goto   +4 more
doaj   +1 more source