Results 51 to 60 of about 8,789,133 (312)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Dissecting the functional and spatial roles of peroxiredoxins as H2O2 scavengers and redox transducers

Cellular and Molecular Life Sciences
Since their discovery in the late 1980s as peroxidases that eliminate hydrogen peroxide (H2O2), peroxiredoxins (Prxs) have been recognized not only for detoxification but also for roles in redox signaling.
Laura de Cubas, Adrian Konopko, Susanna Boronat, José Ayté, Elena Hidalgo   +4 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Targeting the cell cycle in breast cancer: towards the next phase

, 2018
© 2018 Informa UK Limited, trading as Taylor & Francis Group. Deregulation of the cell cycle is a hallmark of cancer that enables limitless cell division.
I Soria-Bretones, Mak, T. W., KL Thu, Thu, K. L., TW Mak, DW Cescon, Cescon, D. W., Soria-Bretones, I.   +7 more
core   +1 more source

CDK activity at the centrosome regulates the cell cycle

Cell Reports
Summary: In human cells and yeast, an intact “hydrophobic patch” substrate docking site is needed for mitotic cyclin centrosomal localization. A hydrophobic patch mutant (HPM) of the fission yeast mitotic cyclin Cdc13 cannot enter mitosis, but whether ...
Emma L. Roberts, Jessica Greenwood, Nitin Kapadia, Tania Auchynnikava, Souradeep Basu, Paul Nurse   +5 more
doaj   +1 more source

Deconstructing the cell cycle [PDF]

Nature Reviews Molecular Cell Biology, 2011
When I was an undergraduate student, knowing three key concepts would ensure success in 'Cell Cycle 101': that oscillations of cyclin–cyclin dependent kinase (CDK) complexes drive the cell cycle; that directionality is ensured by the irreversibility of periodic proteasome-mediated cyclin degradation; and that checkpoints ensure the dependence of later ...
openaire   +3 more sources

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]

, 2003
The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source